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Table 1 Variation in fasting capillary blood glucose over time in experimental groups

From: Combining sodium-glucose co-transporter-2 inhibitor with mesenchymal stem cells and brown adipose tissue (BAT) and white adipose tissue (WAT) transplantation to mitigate the progression of diabetic kidney disease: a pre-clinical approach

Age (weeks)

BTBRob/ob

SGLT2i

SGLT2i + CR

SGLT2i + CR + BM-MSCs

BAT and WAT

Tx

5–6

261(± 103.5)

253.4 (± 99.1)

164.3 (± 38.9)

144.6 (± 29)a,b

180.8 (± 64.3)

7–8

347.9 (± 100.7)

254.3 (± 76.1)

243.4 (± 44.1)

245.9 (± 55.1)a

193.1 (± 43.8)a

9–10

393 (± 113.9)

282 (± 79.3)

282.8 (± 82.7)

289.1 (± 87.9)

189.8 (± 52.7)a,b,c,d

11–12

377 (± 108)

275.6 (± 114.8)

270.6 (± 83.9)

230.5 (± 80.1)a

212.3 (± 41.3)a

14–15

464.8 (± 103.8)

343.3 (± 71.9)a

277.8 (± 81.9)a

203.8 (± 76.7)a,b

187 (± 59.9)a,b

16–17

361.5 (± 76.2)

288.8 (± 84.8)

285.8 (± 124.8)

219.2 (± 76.6)

198.8 (± 88)a

18–20

322.8 (± 72.5)

287.8 (± 94.9)

300.6 (± 85.2)

266.2 (± 115.2)

192.8 (± 31.7)a

  1. a p < 0.05 vs BTBRob/ob, b p < 0.05 vs SGLT2i, c p < 0.05 vs SGLT2i + CR, d p < 0.05 vs SGLT2i + CR + BM-MSCs; mean ± standard deviation. Mixed effect model, with Tukey post-test for multiple comparisons. n = 6–12 animals