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  1. Cancer stem cells (CSCs), refer to small subpopulations of cancer cells within a tumor mass representing stemness properties such as high self-renewal capacities, differentiation potential, metastasis, therapy...

    Authors: Maryam Valizadeh-Otaghsara, Mostafa Haji Molla Hoseini, Saeed Karima, Hakimeh Zali, Kamyar Khoshnevisan and Samira Mohammadi-Yeganeh
    Citation: Stem Cell Research & Therapy 2025 16:576
  2. Bone nonunion or delayed union is a serious complication in diabetic patients with fractures, urgently requiring novel therapeutic strategies. Exosomes derived from stromal cells are naturally occurring nanopa...

    Authors: Liang Tian, Dong Zhang, Zheng Wang, Junwei Su, Changjiang Liu, Chao Jian and Aixi Yu
    Citation: Stem Cell Research & Therapy 2025 16:575
  3. Despite the recognized importance of neutrophils in cardiac repair following myocardial infarction (MI), their interaction with mesenchymal stromal cells (MSCs), particularly regarding polarization phenotypes ...

    Authors: Laudy Cherry, Sinziana Popescu, Carmen Alexandra Neculachi, Evelyn-Gabriela Nastase-Rusu, Catalina Iolanda Marinescu-Colan, Bogdan Paul Cosman, Letitia Ciortan, Fabio Martelli, Maya Simionescu, Elena Butoi, Alexandrina Burlacu and Mihai Bogdan Preda
    Citation: Stem Cell Research & Therapy 2025 16:574
  4. Severely impaired mucociliary airway function is the primary pathomechanism in Cystic Fibrosis (CF) lung disease. Despite significant advances in CF therapy, there is still a critical need for alternative, ind...

    Authors: Mark-Christian Klassen, Anita Balázs, Janina Zöllner, Nicole Cleve, Laurien Czichon, Laura von Schledorn, Jan Hegermann, Janna C. Nawroth, Doris Roth, Mia Mielenz, Silke Hedtfeld, Frauke Stanke, Tihomir Rubil, Fabio Ius, Danny Jonigk, John W. Hanrahan…
    Citation: Stem Cell Research & Therapy 2025 16:573
  5. We commend Cao et al. for their systematic review demonstrating the efficacy of intra-articular mesenchymal stem cell (MSC) therapy in alleviating pain and improving function in patients with non-surgical knee...

    Authors: Shanshan Wu
    Citation: Stem Cell Research & Therapy 2025 16:572
  6. Mesenchymal stromal cells (MSCs) have been used in numerous clinical trials but very few reach phase 3 or market authorisation. Progress is often hampered by the use of non-clonal, heterogeneous and uncharacte...

    Authors: Savvas Ioannou, Alasdair G. Kay, Andrew P. Stone, Emma Rand, Samuel Elberfeld, William Bolton, Tony Larson, Rachel E. Crossland, Oksana Kehoe, David A. Mentlak, Xiao-Nong Wang, Chris MacDonald and Paul G. Genever
    Citation: Stem Cell Research & Therapy 2025 16:571
  7. Parkinson’s disease (PD) is characterized by dopaminergic (DA) neuron degeneration in the substantia nigra pars compacta (SNpc) driven by oxidative stress, inflammation, and impaired neurogenesis. Phloroglucin...

    Authors: Kallolika Mondal, Rituparna Ghanty, Anita Mahadevan, Girish Waghmare, Rashmi Santhoshkumar, Nandeesh BN and Indrani Datta
    Citation: Stem Cell Research & Therapy 2025 16:570
  8. Orthodontic bone remodeling is a complex process involving a dynamic balance between osteogenesis and osteoclast genesis. Although M2 macrophage-derived exosomes (M2-exos) have emerged as key regulators of bon...

    Authors: Mingzhu Chen, Yanjie Li, Zhenjin Yang, Mengting Chen, Junxiong Li, Guangyu Bao, Liya Ma and Jiangtian Hu
    Citation: Stem Cell Research & Therapy 2025 16:569
  9. Pancreatic islet pericytes are emerging as critical regulators of β-cell development, maturation, and function beyond their traditional role in vascular support. While the roles of signaling pathways and trans...

    Authors: Huanjing Bi, Ruiyang Ma, Zuhan Chen, Ying Wang and Xiaoming Ding
    Citation: Stem Cell Research & Therapy 2025 16:568
  10. Human dental pulp stem cells (hDPSCs) possess multipotent properties and play a pivotal role in tissue regeneration. Elucidating the molecular mechanisms governing hDPSC pluripotency is essential for advancing...

    Authors: Kai Zeng, Lijing Wu, Weini Xin, Chen Cui, Sui Mai, Hong Hong and Xi Wei
    Citation: Stem Cell Research & Therapy 2025 16:567
  11. Emerging evidence suggests that paracrine mechanisms may underlie the therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (EVs) (hUCMSC-exos) in mitigating neuroinf...

    Authors: Aobo Zhang, Dan Qiao, Ziyang Jia, Zhanzhan Zhang, Dongdong Yan, Chengrui Nan, Liqiang Liu and Yunpeng Shi
    Citation: Stem Cell Research & Therapy 2025 16:566
  12. Meniscus diseases present certain therapeutic limitations. Although meniscectomy is the primary treatment option for meniscus injury (MI), this approach may accelerate the development of osteoarthritis and oth...

    Authors: Wei-Heng Chen, Wei-Yu Lai, Duy-Cuong Le, Jui-Chien Hsing, Mai-Huong T. Ngo, Cheng-Xiang Kao, Kang-Yun Fan, Gee-Way Lin, Thai-Yen Ling, Yung-Che Kuo and Yen-Hua Huang
    Citation: Stem Cell Research & Therapy 2025 16:565
  13. Mesenchymal stem cells (MSCs) exhibit therapeutic potential for ulcerative colitis (UC) due to their immunomodulatory, homing, and tissue repair capabilities, but clinical efficacy is constrained by heterogene...

    Authors: Lv Tian, Yiming Wang, Lei Shen, Mingru Zong, Jun Fan, Yuxin Lu, Xiaochen Cheng, Li Du, Lin Zhang and Fengjun Xiao
    Citation: Stem Cell Research & Therapy 2025 16:564
  14. The risk of fractures nonunion and delayed union in diabetes mellitus remains elevated despite glucose-lowering therapies. We hypothesized that bone marrow-derived macrophages (BMDMs) can be induced in the sta...

    Authors: Dong Zhang, Changjiang Liu, Ying Yuan, Junwei Su, Zheng Wang, Chao Jian and Aixi Yu
    Citation: Stem Cell Research & Therapy 2025 16:562
  15. Cholesterol, a key steroid in cell membranes and organelles, is vital for processes like migration and apoptosis, regulated by biosynthesis, uptake, and esterification. Its metabolism significantly impacts ste...

    Authors: Boyang Xu, Ling Li, Qian Wei, Yuli Wang, He Huang, Tao Pang, Zhijian Wei, Guoqing Zheng and Yue Li
    Citation: Stem Cell Research & Therapy 2025 16:561
  16. Stromal vascular fraction (SVF) from adipose tissue is a rich and accessible source of regenerative cells, including adipose-derived stem cells (ADSCs). SVF is most commonly isolated from lipoaspirate via enzy...

    Authors: Marcos Sforza, Olga Ivanenko, Nazanin Biabani, Lara Sforza, Deepak M. Kalaskar, Zahra Mohri and Afshin Mosahebi
    Citation: Stem Cell Research & Therapy 2025 16:560
  17. Diabetic foot ulcers (DFUs), which have high rates of recurrence, amputation, and death, are a significant complication in the therapy of diabetes. Chronic inflammation, vascular dysfunction, and peripheral ne...

    Authors: Mohamed S. Kishta, A. M. Hafez, Tamer Hydara, Zeinab Hamed, Mohamed M. Bahr, Ashraf A. Shamaa and Ahmed N. Abdallah
    Citation: Stem Cell Research & Therapy 2025 16:559
  18. With the growing demand for physical activity, there is a large population of patients suffering from ligament injuries, characterized by a high incidence and a need for early return to sports. A critical issu...

    Authors: Jibin Yang, Huaize Dong, Hao Yu, Jin Yang, Yiran Li, Gang Zou and Jiachen Peng
    Citation: Stem Cell Research & Therapy 2025 16:557
  19. Mesenchymal stromal cells exert their immunoregulatory effects through a complex secretome constituted of soluble factors and extracellular vesicles (EVs). While the immunomodulatory activity of the secretome ...

    Authors: Christophe Wong, Isaure Rous, Shony Lemieux, Jeanne Volatron, Nassima Bekaddour, Thibaut Fourniols and Jean-Philippe Herbeuval
    Citation: Stem Cell Research & Therapy 2025 16:556
  20. Bone deficiencies are a major clinical issue for millions worldwide, with challenges to treatment because of donor site morbidity, immunological rejection, and limited integration. Exosomes are endogenously se...

    Authors: Fatemeh Tajafrooz, Sepehr Ghofrani, Fatemeh Sadeghghomi, Ali El Hadi Chamas, Narges Rahimi, Arshia Mirakhor, Mohammad Hosseini Hooshiar and Amir Raee
    Citation: Stem Cell Research & Therapy 2025 16:555
  21. Mitochondrial diseases are a group of serious inherited multisystem disorders caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA and still have faced a significant challenge to therapy due to thei...

    Authors: Zhixin Pu, Peiwen Wang, Mengyao Wang, Yaxin Chen, Yating Zhu, Yuan Jiao, Weiwei Zou, Biao Yu, Huiru Cheng, Yajing Liu, Yunxia Cao, Dongmei Ji and Dan Liang
    Citation: Stem Cell Research & Therapy 2025 16:554
  22. Osteoarthritis (OA), as a complex degenerative disease, involves the interaction among macrophages, chondrocytes and mesenchymal stem cells (MSCs) in its pathogenesis. In recent years, extracellular vesicles (...

    Authors: Hui Kong, Jiale Zheng, Juanjuan Han, Xin Meng, Xinran Li, Xiaodong Wang and Xin-an Zhang
    Citation: Stem Cell Research & Therapy 2025 16:553
  23. This study aimed to evaluate the clinical outcomes of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on ovarian function in women with premature ovarian insufficiency (POI), and its potential to...

    Authors: Chenyang Huang, Na Kong, Pingping Xue, Hui Zhang, Lijun Ding, Lingjuan Wang, Jianjun Zhou, Jun Xing, Jie Mei and Haixiang Sun
    Citation: Stem Cell Research & Therapy 2025 16:552
  24. Myocardial infarction (MI) and atherosclerosis (AS) are the deadliest category of diseases globally. Preliminary clinical and preclinical studies have shown that stem cell therapy can alleviate symptoms; howev...

    Authors: Xingchen Wan, Chenyan Qian, Siyi Liu, Yue Xu, Jinghua Yuan, Xinling Zhang and Xiaoping Li
    Citation: Stem Cell Research & Therapy 2025 16:551
  25. Authors: Feng Ye, Jinteng Li, Peitao Xu, Zhongyu Xie, Guan Zheng, Wenjie Liu, Guiwen Ye, Wenhui Yu, Jiajie Lin, Zepeng Su, Yunshu Che, Zhaoqiang Zhang, Peng Wang, Yanfeng Wu and Huiyong Shen
    Citation: Stem Cell Research & Therapy 2025 16:550
  26. Mesenchymal stem/stromal cells (MSCs) have shown significant therapeutic effects in a range of autoimmune and hyperinflammatory diseases through their strong immunomodulatory properties, both in animal models ...

    Authors: Tingting Wang, Yanan Li, Jinyi Tian, Guofu Sun, Tingting Yang, Zhenzhen Meng, Wen Li, Xiao Su, Rui Liu, Pixia Gong, Lijuan Cao, Chao Feng, Dongyan Zhao, Peishan Li, Yufang Shi, Jiankai Fang…
    Citation: Stem Cell Research & Therapy 2025 16:548
  27. Regenerative therapies are quickly expanding to application in equine patients because of their importance as sporting and companion animals. Furthermore, aligning with a One Health concept, veterinary medicin...

    Authors: Laura Barrachina, Ana Ivanovska, Tarlan Eslami Arshaghi, Aisling O’Brien, Alina Cequier, Mary Murphy, Fiona Hollinshead, Clementina Rodellar and Frank Barry
    Citation: Stem Cell Research & Therapy 2025 16:547
  28. Mitochondrial dysfunction is a pivotal factor in the progression of various diseases, making it a critical therapeutic target. Mesenchymal stromal cells (MSCs) have shown promise in mitigating this dysfunction...

    Authors: Huan Chen, Xu Chen, Zi-hao Zhou, Jia-rong Zheng, Ye Lu, Pei Lin, Yun-fan Lin, Yu-cheng Zheng, Bin Xiong, Rong-wei Xu, Li Cui and Xin-yuan Zhao
    Citation: Stem Cell Research & Therapy 2025 16:546
  29. Sarcopenia, a progressive age-related decline in skeletal muscle mass and function, is closely linked to impaired regenerative capacity of satellite cells (SCs), also known as satellite cells. Age-dependent SC...

    Authors: Na Li, Yushu Chen, Qiong Wang, Xiaoqin Liu, Chao Han, Chao Qu, Xin Guan, Wei Zou, Xiaomin Wang, Ang Li, Jing Liu and Yanfu Wang
    Citation: Stem Cell Research & Therapy 2025 16:545
  30. Traumatic brain injury (TBI) leads to secondary injuries, such as neuroinflammation and brain dysfunction, which is a critical challenge in clinical treatment. The use of bone marrow mesenchymal stem cells (BM...

    Authors: Li Chen, Yang Yang, Junwei Chen, Yinghong Lin, Liang Xian, Yuhui Chen, Xingshu Zhu, Ying Tang, Yi Zuo, Shaohuai Xia, Xuewei Xia, Yongjun Xu and Shousen Wang
    Citation: Stem Cell Research & Therapy 2025 16:544
  31. The generation of functionally mature hepatocytes from human induced pluripotent stem cells (iPSC) has the potential to replace primary human hepatocytes (PHH) as the gold standard in vitro model for drug scre...

    Authors: Patrick Nell, Antonia Thomitzek, David Feuerborn, Andreas Scholtz-Illigens, Sarah M. Seidel, Katharina Derksen, Lara Maria Chilinski, Kathrin Kattler-Lackes, Nils Blüthgen, Markus Morkel, Jörn Walter, Karolina Edlund, Jörg Rahnenführer and Jan G. Hengstler
    Citation: Stem Cell Research & Therapy 2025 16:543
  32. The intricate process of tissue regeneration, driven by endogenous mechanisms, represents a sophisticated interplay of biological events from injury detection to functional recovery. This review discusses the ...

    Authors: M. Amin Sharifi, Nor Faissal Yasin, Tunku Kamarul and Ali M. Sharifi
    Citation: Stem Cell Research & Therapy 2025 16:541
  33. To investigate the role of PD-1+CXCR5-CD4+ peripheral helper T (Tph) cells in patients with primary Sjogren’s syndrome (pSS) and to assess the therapeutic efficacy of mesenchymal stromal cells (MSC) in pSS patien...

    Authors: Shiyi Zhang, Fanzhang Yin, Rui Chai, Tao Li, Yingying Gao, Xiaoxiang Chen, Genhong Yao, Xiaojun Tang, Xiaojuan Han, Betty P. Tsao, Linyu Geng and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2025 16:540
  34. Acute lung injury (ALI) is a critical pulmonary condition characterized by high morbidity and mortality rates. Recent studies have highlighted the therapeutic potential of engineered exosomes derived from mese...

    Authors: Yunjuan Wang, Jiayan Huang, Yanli An, Yaqi Li, Shuanglong Chen, Yuting Mei, Dongfang Liu and Qiusha Tang
    Citation: Stem Cell Research & Therapy 2025 16:539
  35. Facial infiltrating lipomatosis (FIL) is a rare congenital disorder characterized by adipose hyperplasia and osseous overgrowth, driven by somatic PIK3CA mutations. While PIK3CA-induced metabolic reprogramming...

    Authors: Hongrui Chen, Chen Hua, Shih-Jen Chang, Yajing Qiu, Xiaoxi Lin and Bin Sun
    Citation: Stem Cell Research & Therapy 2025 16:538
  36. Unexplained recurrent spontaneous abortion (URSA) is a distressing pregnancy disorder with no effective medical intervention. As a potential treatment for URSA, human umbilical cord mesenchymal stem cells (huc...

    Authors: Zhan Shi, Xiaowen Lu, Haiyi Fei, Xiu Liu, Shiqian Xu, Yuhan Lin, Ling Fang, Lingling Jiang and Songying Zhang
    Citation: Stem Cell Research & Therapy 2025 16:537
  37. Head and neck cancer (HNC), which refers to a heterogeneous group of malignancies, is a serious threat to human health. Its pathogenesis is complex, and the treatment faces many challenges. As an emerging in v...

    Authors: Ruoyu Meng, Lianpin Yu, Xiaomei Li, Na Ning, Haibin Hao, Xiaonan Zhang, Jiabing Kong, Wei Song and Xinyu Li
    Citation: Stem Cell Research & Therapy 2025 16:534
  38. Silicosis is an occupational lung disease characterized by silicotic nodules and progressive pulmonary fibrosis, caused by long-term excessive inhalation of free silica. So far, no effective methods have been ...

    Authors: Liyuan Zhao, Yiwen Tang, Bingbing Wu, Yan Gao, Xi Shen, Zhenghao Liu, Shuyu Xiao, Sanqiao Yao, Jinlong Li and Fuhai Shen
    Citation: Stem Cell Research & Therapy 2025 16:533
  39. Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain. Existing literature has confirmed the occurrence of ferroptosis in IVDD. With the widespread application of artificial intell...

    Authors: Hua Sun, Xuan You, Zhaoyu Li, Zhengguang Li, Benkui Hua, Chen Liu, Yongbo Zhang, Huofeng Wu, Shuangjia Zai and Liang Zhang
    Citation: Stem Cell Research & Therapy 2025 16:531
  40. Generating expanded potential stem cells from cloned porcine embryos (pEPSCsNT) represents a notable advancement in regenerative medicine and agricultural biotechnology. However, challenges, including low derivat...

    Authors: Lian Cai, Mirae Kim, Hyerin Choi, Haneul Kim, Sang-Hwan Hyun and Eunhye Kim
    Citation: Stem Cell Research & Therapy 2025 16:527
  41. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) can reverse senescence after acute kidney injury (AKI) via maintaining mitochondrial homeostasis. Copper accumulation and STAT3 nuclear translocat...

    Authors: Kaiting Zhuang, Wenjuan Wang, Cheng Xu, Siyang Wang, Yuhao Chen, Yingjie Zhang, Yanjun Liang, Xumin Zheng, Xiangmei Chen, Zhe Feng and Guangyan Cai
    Citation: Stem Cell Research & Therapy 2025 16:526
  42. This is a phase I trial, assessing the feasibility, safety, and potential efficacy of intradiscal injection of allogeneic bone marrow-derived clonal mesenchymal stromal cells (BM-cMSCs) in patients suffering f...

    Authors: Alireza Beheshti Maal, Ramin Kordi, Hoda Madani, Masoud Khadivi, Navid Moghadam, Ali Asnaashari, Majid Najafi, Mohamadreza Baghaban Eslaminejad, Shayan Farzanbakhsh, Hamidreza Hghighatkhah, Bahareh Sadri, Shahedeh Karimi, Ensiyeh Hajizadeh-Saffar, Nafiseh Hassani, Hossein Baharvand and Massoud Vosough
    Citation: Stem Cell Research & Therapy 2025 16:525
  43. Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients taking bisphosphonates. This study aimed at developing a mesenchymal stem cell-based strategy to reduce the incidence o...

    Authors: Che-Chang Tu, Ming-Hsu Chen, Guan-Yu Lan, Yu-Ting Lin, Yu-Tse Lin, Wei-Chiu Tai, Jiashing Yu and Po-Chun Chang
    Citation: Stem Cell Research & Therapy 2025 16:524

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