Page 1 of 103
Cancer stem cells (CSCs), refer to small subpopulations of cancer cells within a tumor mass representing stemness properties such as high self-renewal capacities, differentiation potential, metastasis, therapy...
Bone nonunion or delayed union is a serious complication in diabetic patients with fractures, urgently requiring novel therapeutic strategies. Exosomes derived from stromal cells are naturally occurring nanopa...
Despite the recognized importance of neutrophils in cardiac repair following myocardial infarction (MI), their interaction with mesenchymal stromal cells (MSCs), particularly regarding polarization phenotypes ...
Severely impaired mucociliary airway function is the primary pathomechanism in Cystic Fibrosis (CF) lung disease. Despite significant advances in CF therapy, there is still a critical need for alternative, ind...
We commend Cao et al. for their systematic review demonstrating the efficacy of intra-articular mesenchymal stem cell (MSC) therapy in alleviating pain and improving function in patients with non-surgical knee...
Mesenchymal stromal cells (MSCs) have been used in numerous clinical trials but very few reach phase 3 or market authorisation. Progress is often hampered by the use of non-clonal, heterogeneous and uncharacte...
Parkinson’s disease (PD) is characterized by dopaminergic (DA) neuron degeneration in the substantia nigra pars compacta (SNpc) driven by oxidative stress, inflammation, and impaired neurogenesis. Phloroglucin...
Orthodontic bone remodeling is a complex process involving a dynamic balance between osteogenesis and osteoclast genesis. Although M2 macrophage-derived exosomes (M2-exos) have emerged as key regulators of bon...
Pancreatic islet pericytes are emerging as critical regulators of β-cell development, maturation, and function beyond their traditional role in vascular support. While the roles of signaling pathways and trans...
Human dental pulp stem cells (hDPSCs) possess multipotent properties and play a pivotal role in tissue regeneration. Elucidating the molecular mechanisms governing hDPSC pluripotency is essential for advancing...
Emerging evidence suggests that paracrine mechanisms may underlie the therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (EVs) (hUCMSC-exos) in mitigating neuroinf...
Meniscus diseases present certain therapeutic limitations. Although meniscectomy is the primary treatment option for meniscus injury (MI), this approach may accelerate the development of osteoarthritis and oth...
Mesenchymal stem cells (MSCs) exhibit therapeutic potential for ulcerative colitis (UC) due to their immunomodulatory, homing, and tissue repair capabilities, but clinical efficacy is constrained by heterogene...
The manufacturing of stem cell-based therapeutics hinges on models linking product characteristics to bioprocess conditions and cellular physiology. Typical quantitative models of cellular systems rely on popu...
The risk of fractures nonunion and delayed union in diabetes mellitus remains elevated despite glucose-lowering therapies. We hypothesized that bone marrow-derived macrophages (BMDMs) can be induced in the sta...
Cholesterol, a key steroid in cell membranes and organelles, is vital for processes like migration and apoptosis, regulated by biosynthesis, uptake, and esterification. Its metabolism significantly impacts ste...
Stromal vascular fraction (SVF) from adipose tissue is a rich and accessible source of regenerative cells, including adipose-derived stem cells (ADSCs). SVF is most commonly isolated from lipoaspirate via enzy...
Diabetic foot ulcers (DFUs), which have high rates of recurrence, amputation, and death, are a significant complication in the therapy of diabetes. Chronic inflammation, vascular dysfunction, and peripheral ne...
The original article was published in Stem Cell Research & Therapy 2025 16:276
With the growing demand for physical activity, there is a large population of patients suffering from ligament injuries, characterized by a high incidence and a need for early return to sports. A critical issu...
Mesenchymal stromal cells exert their immunoregulatory effects through a complex secretome constituted of soluble factors and extracellular vesicles (EVs). While the immunomodulatory activity of the secretome ...
Bone deficiencies are a major clinical issue for millions worldwide, with challenges to treatment because of donor site morbidity, immunological rejection, and limited integration. Exosomes are endogenously se...
Mitochondrial diseases are a group of serious inherited multisystem disorders caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA and still have faced a significant challenge to therapy due to thei...
Osteoarthritis (OA), as a complex degenerative disease, involves the interaction among macrophages, chondrocytes and mesenchymal stem cells (MSCs) in its pathogenesis. In recent years, extracellular vesicles (...
This study aimed to evaluate the clinical outcomes of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on ovarian function in women with premature ovarian insufficiency (POI), and its potential to...
Myocardial infarction (MI) and atherosclerosis (AS) are the deadliest category of diseases globally. Preliminary clinical and preclinical studies have shown that stem cell therapy can alleviate symptoms; howev...
Mesenchymal stem/stromal cells (MSCs) have shown significant therapeutic effects in a range of autoimmune and hyperinflammatory diseases through their strong immunomodulatory properties, both in animal models ...
Regenerative therapies are quickly expanding to application in equine patients because of their importance as sporting and companion animals. Furthermore, aligning with a One Health concept, veterinary medicin...
Mitochondrial dysfunction is a pivotal factor in the progression of various diseases, making it a critical therapeutic target. Mesenchymal stromal cells (MSCs) have shown promise in mitigating this dysfunction...
Sarcopenia, a progressive age-related decline in skeletal muscle mass and function, is closely linked to impaired regenerative capacity of satellite cells (SCs), also known as satellite cells. Age-dependent SC...
Traumatic brain injury (TBI) leads to secondary injuries, such as neuroinflammation and brain dysfunction, which is a critical challenge in clinical treatment. The use of bone marrow mesenchymal stem cells (BM...
The generation of functionally mature hepatocytes from human induced pluripotent stem cells (iPSC) has the potential to replace primary human hepatocytes (PHH) as the gold standard in vitro model for drug scre...
PD0325901 generates functional astrocytes from gliogenic human NSCs in 2 weeks.
The intricate process of tissue regeneration, driven by endogenous mechanisms, represents a sophisticated interplay of biological events from injury detection to functional recovery. This review discusses the ...
To investigate the role of PD-1+CXCR5-CD4+ peripheral helper T (Tph) cells in patients with primary Sjogren’s syndrome (pSS) and to assess the therapeutic efficacy of mesenchymal stromal cells (MSC) in pSS patien...
Acute lung injury (ALI) is a critical pulmonary condition characterized by high morbidity and mortality rates. Recent studies have highlighted the therapeutic potential of engineered exosomes derived from mese...
Facial infiltrating lipomatosis (FIL) is a rare congenital disorder characterized by adipose hyperplasia and osseous overgrowth, driven by somatic PIK3CA mutations. While PIK3CA-induced metabolic reprogramming...
Unexplained recurrent spontaneous abortion (URSA) is a distressing pregnancy disorder with no effective medical intervention. As a potential treatment for URSA, human umbilical cord mesenchymal stem cells (huc...
The original article was published in Stem Cell Research & Therapy 2025 16:110
Head and neck cancer (HNC), which refers to a heterogeneous group of malignancies, is a serious threat to human health. Its pathogenesis is complex, and the treatment faces many challenges. As an emerging in v...
Silicosis is an occupational lung disease characterized by silicotic nodules and progressive pulmonary fibrosis, caused by long-term excessive inhalation of free silica. So far, no effective methods have been ...
Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain. Existing literature has confirmed the occurrence of ferroptosis in IVDD. With the widespread application of artificial intell...
Diabetic retinopathy (DR) is a leading cause of blindness in adults, which is characterized by neurovascular dysfunction. Retinal neurodegeneration was involved in the pathogenesis of early-stage DR. This rese...
Generating expanded potential stem cells from cloned porcine embryos (pEPSCsNT) represents a notable advancement in regenerative medicine and agricultural biotechnology. However, challenges, including low derivat...
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) can reverse senescence after acute kidney injury (AKI) via maintaining mitochondrial homeostasis. Copper accumulation and STAT3 nuclear translocat...
This is a phase I trial, assessing the feasibility, safety, and potential efficacy of intradiscal injection of allogeneic bone marrow-derived clonal mesenchymal stromal cells (BM-cMSCs) in patients suffering f...
Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients taking bisphosphonates. This study aimed at developing a mesenchymal stem cell-based strategy to reduce the incidence o...
Citation Impact
Journal Impact Factor: 7.3 (2024)
5-year Journal Impact Factor: 7.9 (2024)
Source Normalized Impact per Paper (SNIP): 1.427 (2024)
SCImago Journal Rank (SJR): 2.021 (2024)
Speed
Submission to first editorial decision (median days): 16
Submission to acceptance (median days): 126
Usage 2024
Downloads: 4,339,054
Altmetric mentions: 1,003
Stem Cell Research & Therapy