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    Arthritis patients exhibit a higher stroke risk, but effective predictive biomarkers are scarce. This research sought to examine and compare the associations between the triglyceride-glucose (TyG) index, its i...

    Authors: Zhongwei Zhou, Jianshu Gao, Mingzhong Sun, Hongmei Chen, Hao Jin and Huixiang Ju
    Citation: Lipids in Health and Disease 2025 24:341
    Content type: Research Published on:

  2. Smith-Lemli-Opitz syndrome (SLOS) is a rare autosomal recessive disorder of cholesterol biosynthesis. SLOS leads to increased levels of 7-dehydrocholesterol (7-DHC) and decreased levels of total cholesterol (T...

    Authors: Tobias Fischer, Alicia Born, Simone Harmeling, Manfred Fobker, Ulrike Och, Christiane Elpers and Thorsten Marquardt
    Citation: Lipids in Health and Disease 2025 24:340
    Content type: Research Published on:

  3. Definitions of nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated FLD (MAFLD), and steatotic liver disease (SLD) have been proposed to better guide clinical practice and epidemiological...

    Authors: Liangguang Xiang, Xiaoyun Li, Jiamin Gong, Long He, Wanxin Li, Jun Chen, Ruimei Feng, Shanshan Du and Weimin Ye
    Citation: Lipids in Health and Disease 2025 24:339
    Content type: Research Published on:

  4. Post-induction hypotension (PIH) is a frequent complication during general anesthesia and is linked to adverse outcomes. Abnormalities in serum total cholesterol (TC) have been associated with blood pressure d...

    Authors: Yiying Yang, Chao Gong, Hui Jiang, Zhenyu Luo and Lianhua Chen
    Citation: Lipids in Health and Disease 2025 24:338
    Content type: Research Published on:

  5. Subclinical hypothyroidism (SCH) often occurs in association with the emergence of the metabolic disorder like insulin resistance (IR). This study aimed to determine the relationship between the Triglyceride G...

    Authors: Fawad Inayat, Sulaiman Shams, Noor Ullah, Arsalan Waqas Ahmad Shah and Ihtesham Ul Haq
    Citation: Lipids in Health and Disease 2025 24:337
    Content type: Research Published on:

  6. Aquaporins (AQPs), mainly divided into classical AQPs, aquaglyceroporins, and superaquaporins, constitute a channel protein family facilitating the movement of small molecules, such as H2O, H2O2, and glycerol, ac...

    Authors: Yingwei Bi, Shuo Pang, Yuxin Liu, Jiani Cheng, Qifeng Ma, Ao Song, Xiaoqing Yin and Jianbo Wang
    Citation: Lipids in Health and Disease 2025 24:336
    Content type: Review Published on:

  7. Limited studies demonstrated the relationships between first-trimester maternal dyslipidemia and adverse pregnancy-offspring complications. This investigation aimed to probe (1) the relationships of first-trim...

    Authors: Jinnan Liu, Qiangrong Zhai, Jing Wang, Xi Li, Jiayu Chen, Yuanyuan Guo, Fengxia Su, Chang Jiang, Fangyi Ren, Min Li, Guohong Zhang, Gongshu Liu, Ya Gao and Shuo Wang
    Citation: Lipids in Health and Disease 2025 24:335
    Content type: Research Published on:

  8. The interplay between skeletal muscle loss and excess adiposity has been associated with metabolic dysfunction and may impose a dual burden on physiological homeostasis. This study aimed to investigate the ass...

    Authors: Ruolin Wang, Lei Cao, Peng Zhang, Hailong Chen, Qi Zhong, Ziqi Sang, Chunwei Wu and Ze He
    Citation: Lipids in Health and Disease 2025 24:334
    Content type: Research Published on:

  9. Pulmonary arterial hypertension (PAH) is a devastating disease complicated by pathological features such as proliferation of pulmonary artery smooth muscle cells (PASMCs), vasoconstriction, increased pulmonary...

    Authors: Baishi Huang, Yu Hao, Zhe Wen, Jie Dong, Shengwei Jin and Hui Li
    Citation: Lipids in Health and Disease 2025 24:333
    Content type: Review Published on:

  10. Intensive care unit-acquired weakness (ICU-AW) represents a prevalent and debilitating complication among critically ill patients, distinguished by profound skeletal muscle atrophy and functional deterioration...

    Authors: Min Li, Luying Yang, Ting Li, Yanmei Miao, Jun Yang, Shaolin Chen, Xinglong Ma and Peng Xie
    Citation: Lipids in Health and Disease 2025 24:332
    Content type: Review Published on:

  11. As global obesity rates rise, women are disproportionately affected, placing them at elevated risk for both metabolic dysfunction and cardiovascular complications. This study investigated the expression of Krüppe...

    Authors: Dalya Jamal Muhi, Maher Mohammed Murad, Ghodratollah Panahi, Hossein Zabihi-Mahmoudabadi, Solaleh Emamgholipour and Azin Nowrouzi
    Citation: Lipids in Health and Disease 2025 24:331
    Content type: Research Published on:

  12. Postoperative delirium (POD) after cardiac surgery correlates with adverse outcomes, increasing healthcare burdens and hindering patient recovery.The triglyceride-glucose (TyG) index, a marker of insulin resis...

    Authors: Jia Zeng, Nanxi Li, Caifeng Ma, Yuqi Song, Weikun Tian, Ya Gao, Shuo Tang, Xiangtian Liu and Xinghan Tian
    Citation: Lipids in Health and Disease 2025 24:330
    Content type: Research Published on:

  13. This study aimed to evaluate the association between mammary intraductal secretions (IDS) and demographic characteristics, clinical manifestations, laboratory indicators and prognosis in patients with non-puer...

    Authors: Wenchao Qu, Jiaye Sun, Shijun Shao, Jiamei Feng, Qingqian Gao, Lu Xie, Xueqing Wu and Hua Wan
    Citation: Lipids in Health and Disease 2025 24:329
    Content type: Research Published on:

  14. Sepsis is a severe and frequent complication among ischemic stroke patients during hospitalization. The atherogenic index of plasma (AIP), as metabolism-related markers, are closely linked to inflammation. How...

    Authors: Fengwei Yao, Lei Liu, Jian Zhang, Xiaolan Chen and Zhijun He
    Citation: Lipids in Health and Disease 2025 24:328
    Content type: Research Published on:

  16. With the rising proportion of recipients with type 2 diabetes (T2D) undergoing simultaneous pancreas-kidney transplantation (SPK), cardiovascular complications remain the leading cause of post-transplant morta...

    Authors: Jianming Zheng, Yu Cao, Hui Wang, Xiaofeng Shi, Jianghao Wei, Liping Guo, Panpan Zhan and Wenli Song
    Citation: Lipids in Health and Disease 2025 24:326
    Content type: Research Published on:

  17. Frailty represents a common condition among older individuals, linked to heightened vulnerabilities for negative health effects and death. The ratio of uric acid (UA) to high-density lipoprotein cholesterol (H...

    Authors: Yongwei Huang, Xiaoyi Wang, Xiaoshuang Yin and Zongping Li
    Citation: Lipids in Health and Disease 2025 24:325
    Content type: Research Published on:

  18. The potential association between short-chain fatty acids (SCFAs) and aging has gained increasing research attention. Although most studies have focused on fecal SCFAs, limited attention has been directed towa...

    Authors: Xiaopeng Chen, Songyuan Ye, Juncai Pu, Siwen Gui, Dongfang Wang, Xiaogang Zhong, Weiyi Chen, Yue Chen, Xiang Chen, Yanyi Jiang, Renjie Qiao, Yiyun Liu and Peng Xie
    Citation: Lipids in Health and Disease 2025 24:324
    Content type: Research Published on:

  19. The metabolic score for insulin resistance (METS-IR) is a novel indicator used to assess insulin resistance. Previous studies have shown that it is associated with an increased risk of hypertension. However, i...

    Authors: Qiong Li, Jing Yan, Chenyang Zhao, Meng Li, Ying Gu, Bingshun Wang, Yangjing Pang and Chaoyan Yue
    Citation: Lipids in Health and Disease 2025 24:323
    Content type: Research Published on:

  20. Improving the accuracy of 10-year cardiovascular risk prediction beyond established algorithms like SCORE2 is a clinical priority. The plasma ratio of polyunsaturated to monounsaturated fatty acids (PUFA/MUFA)...

    Authors: Meiyan Sun, Dandan Jiang, Xueqin Long and Xuemei Chen
    Citation: Lipids in Health and Disease 2025 24:322
    Content type: Research Published on:

  21. Small dense low-density lipoprotein cholesterol (sdLDL-C) refers to an atherogenic subclass of lipoproteins. Owing to limited access to direct measurement in routine clinical settings, several estimation formu...

    Authors: Yichen Ma, Xiaobing Zhai, Danni Mu, Yumeng Gao, Yuemeng Li, Ling Qiu, Kefeng Li and Xinqi Cheng
    Citation: Lipids in Health and Disease 2025 24:321
    Content type: Research Published on:

  22. A new way to measure the capability of food to inhibit oxidation is the “composite dietary antioxidant index” (CDAI), which helps determine whether sarcopenia progresses because of oxidative stress. Using “Nat...

    Authors: Jue Zhang and Huan Shi
    Citation: Lipids in Health and Disease 2025 24:320
    Content type: Research Published on:

  23. Plasma apolipoproteins are linked to cardiometabolic dysfunctions, but their potential as biomarkers for metabolic dysfunction-associated steatohepatitis (MASH) remains underexplored.

    Authors: Zichun Cai, Souad Najib, María A. Núñez-Sánchez, María A. Martínez-Sánchez, Carmen García-Melgares, Nathalie Viguerie, Joana Rossell, Josep Julve, Mikaël Croyal, Arsênio Rodrigues Oliveira, Carlos M. Martínez, Sébastien J. Dumas, Annelise Genoux, María D. Frutos, Bruno Ramos-Molina and Laurent O. Martinez
    Citation: Lipids in Health and Disease 2025 24:319
    Content type: Research Published on:

  25. To examine the association between insulin sensitivity, measured by estimated glucose disposal rate (eGDR), and the onset, progression, and prognosis of cardiometabolic multimorbidity (CMM) and all-cause morta...

    Authors: Wenke Cheng, Xinru Feng, Pinfang Kang, Jinjun Liu and Bi Tang
    Citation: Lipids in Health and Disease 2025 24:317
    Content type: Research Published on:

  26. The associations between metabolic dysfunction-associated fatty liver disease (MAFLD) and its subtypes (diabetes mellitus [DM]-MAFLD, overweight [OW]-MAFLD, and lean MAFLD) with carotid and femoral atheroscler...

    Authors: Zhenzhen Li, Sisi Jiang, Ruotian Chen, Zihan Zhang, Lijun Zheng, Heng He, Ruimei Feng, Shanshan Du, Weihong Qiu and Weimin Ye
    Citation: Lipids in Health and Disease 2025 24:316
    Content type: Research Published on:

  27. Recent studies suggest a link between residual cholesterol (RC) and hypertension, but the mechanisms remain unclear. Exploring modifiable factors like RC may contribute to chronic disease management.

    Authors: Tian-Qi Teng, Jing Liu, Meng-Meng Wang, Ya-Qin Chen, Jia-Chao Xu, Zi-Han Dong, Qing-Ying Jiao, Ning Zhang and Hai-Chu Yu
    Citation: Lipids in Health and Disease 2025 24:315
    Content type: Research Published on:

  29. Kidney Yang deficiency (KYD) is associated with disturbances in glucose and lipid metabolism. This study examined whether KYD rats on a high-fat diet (HFD) exhibit aggravated metabolic dysfunction and sought t...

    Authors: Han Li, Yunqiao Wang, Wei Zheng, Jing Lu, Cuiyao Tang, Mengyang Long, Bo Liu, Bin Chen, Weihong Li and Zihui Xu
    Citation: Lipids in Health and Disease 2025 24:313
    Content type: Research Published on:

  30. Chronic continuous hypoxia imposes a huge physiological burden and impacts human health. The liver is critical for maintaining whole-body homeostasis. Although accumulating evidence has linked hypoxia to liver...

    Authors: Yujie Huang, Yu Ding, Xiaoyu Guo, Lingfang Huang, Xiangqiong Meng, Wenjun Jiang, Zejun Wang, Tian Yang, Minghai Zheng and Xiaoling Tan
    Citation: Lipids in Health and Disease 2025 24:312
    Content type: Research Published on:

  31. Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder associated with reproductive and metabolic dysfunction. Emerging evidence indicates that the lipid accumulation product (LAP) and visceral adi...

    Authors: Mohammadamin Parsaei, Elaheh Karimi, Amirali Barkhordarioon, Mohammadreza Yousefi and Azadeh Tarafdari
    Citation: Lipids in Health and Disease 2025 24:311
    Content type: Review Published on:

  32. Polycystic ovary syndrome (PCOS) is a multifactorial metabolic–endocrine disorder in women of reproductive age in which lipid metabolism disorders and chronic low-grade inflammation reinforce and amplify each ...

    Authors: Wenwen Yang, Nan Pang and Xiaoxia He
    Citation: Lipids in Health and Disease 2025 24:310
    Content type: Review Published on:

  33. The triglyceride-glucose index (TyG) and C-reactive protein (CRP) are key biomarkers on clinical diagnosis, each related to lung dysfunction. However, the relationship of both indexes with the risk of chronic ...

    Authors: Jialiu He, Mengxia Li, Pengfei Luo, Zheng Zhu, Jian Su, Ran Tao, Jinyi Zhou, Ming Wu and Xikang Fan
    Citation: Lipids in Health and Disease 2025 24:309
    Content type: Research Published on:

  34. Among individuals diagnosed with type 2 diabetes mellitus (T2DM), an abnormal accumulation of visceral fat heightens the cardiovascular risk (CVR), and the major reason for death for these people is atheroscle...

    Authors: Jing Jin, Yu Lei, Jia Zheng, Jinjian Xu, Linna Chen, Shuning Liu, Xingyue Cao, Ye Hu, Chenyan Yan and Xiaohong Wu
    Citation: Lipids in Health and Disease 2025 24:308
    Content type: Research Published on:

  35. MLN4924 is a novel small molecule inhibitor of neddylation. During clinical trials, it has demonstrated promising therapeutic efficacy in hematological malignancies, lung cancer, and colon cancer. MLN4924 poss...

    Authors: Lei Xing, Yu Bu, Jingqi Shi, Jing Liu, Fan Hu, Minghua Zhang and Jiao Fan
    Citation: Lipids in Health and Disease 2025 24:307
    Content type: Research Published on:

  36. Evidence linking urinary metabolites of volatile organic compounds (UMVOCs) to dyslipidemia remains limited and scarce. This research sought to thoroughly clarify the UMVOCs-dyslipidemia associations and evalu...

    Authors: Lili Wu, Zhihang Ma, Yan Ma and Jing Gao
    Citation: Lipids in Health and Disease 2025 24:306
    Content type: Research Published on:

  37. Intervertebral disc degeneration (IVDD) is the primary cause of low back pain (LBP). Dyslipidaemia can induce a chronic inflammatory state in the body, promote the polarization of macrophages, and may affect t...

    Authors: Sheng-Jie Chang, Hao-Wei Xu, Shu-Bao Zhang, Xiao-Wei Liu, Yu-Yang Yi and Shan-Jin Wang
    Citation: Lipids in Health and Disease 2025 24:305
    Content type: Research Published on:

  38. While cotrimoxazole has anti-inflammatory effects among people with Human Immunodeficiency Virus (PWH), its effect on lipid profiles is not well-characterized. We compared the lipid profiles of PWH on cotrimox...

    Authors: Joseph Baruch Baluku, Martin Nabwana, Ronald Olum, George Patrick Akabwai and Felix Bongomin
    Citation: Lipids in Health and Disease 2025 24:304
    Content type: Research Published on:

  39. While prior meta-analyses have demonstrated the benefits of lipid-lowering agents for atherosclerotic cardiovascular disease prevention in high-risk populations with definite risk, the applicability of these f...

    Authors: Xuefan Yao, Houlin Lai, Kehui Ma, Benke Zhao, Aini He, Wei Sun, Yuan Wang and Haiqing Song
    Citation: Lipids in Health and Disease 2025 24:303
    Content type: Research Published on:

  40. Neovascular age-related macular degeneration (nAMD) is a major aetiology of vision loss characterized by lipid metabolism dysregulation. This study investigated the alterations in lipid profiles associated wit...

    Authors: Yuan Qu, Yujuan Liu, Junwei Fang, Chong Chen, Lu Cheng, Xiaoyin Xu, Jing Jin, Xia Chen, Tian Niu, Hanying Wang, Xindan Xing, Xin Shi, Yinchen Shen and Kun Liu
    Citation: Lipids in Health and Disease 2025 24:302
    Content type: Research Published on:

  41. Lipoprotein particle (p) size and count beyond lipoprotein lipid content [triglycerides (tg) and cholesterol (c)] are critical for their atherogenicity. This study characterized lipoprotein profiles in metabol...

    Authors: Victoria Santisteban, Anallely López-Yerena, Natàlia Muñoz-Garcia, Gemma Vilahur, Lina Badimon and Teresa Padro
    Citation: Lipids in Health and Disease 2025 24:301
    Content type: Research Published on:

  42. Hyperlipidemia is the most prevalent cardiovascular (CV) risk factors. We aimed to analyze the distribution of lipid parameters and clinical variables associated with elevated and non-elevated selected lipid f...

    Authors: Marcin Ziółkowski, Jakub Ratajczak, Karolina Obońska, Piotr Adamski, Maciej Banach, Krzysztof Chlebus, Maciej Grymuza, Klaudyna Grzelakowska, Piotr Jankowski, Jacek Konarski, Ewa Laskowska, Piotr Niezgoda, Małgorzata Ostrowska, Elżbieta Ozorowska, Przemysław Podhajski, Jacek Przybylski…
    Citation: Lipids in Health and Disease 2025 24:300
    Content type: Research Published on:

  43. Population aging has increased the demand for intensive care, with critically ill patients facing high mortality and prolonged hospital stays. New biomarkers are needed to predict outcomes early. The C-reactiv...

    Authors: Huijian Wang, Longlong Hu, Yang Chen, Huabin He, Yijun Huang, Ruyi Tao, Shiyuan Li and Renqiang Yang
    Citation: Lipids in Health and Disease 2025 24:299
    Content type: Research Published on:

  44. Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a significant and growing global health challenge. This study leverages the Global Burden of Disease (GBD) 2021 database to analyze the ep...

    Authors: Juanjuan Zeng, Changhao Gu, Congle Wen and Chenchen Shen
    Citation: Lipids in Health and Disease 2025 24:298
    Content type: Research Published on:

  45. Metabolic associated fatty liver disease (MAFLD) has emerged as the most common chronic liver disease worldwide. However, effective pharmacological treatments remain limited. Dysregulated lipid metabolism and ...

    Authors: Wen-Cheng Liu, Chih-Feng Lien, Yi-Jhen Huang, Pei-Yu Lien, Sy-Jou Chen, Chin-Sheng Lin, Rou-Ling Cho and Yi-Ping Chuang
    Citation: Lipids in Health and Disease 2025 24:296
    Content type: Research Published on:

  46. Previous studies have shown that obesity and metabolic and psychological factors are related to cardiometabolic comorbidities, and this study focuses on the BRI, TyG index and depression and explores the indep...

    Authors: Qinglin He, Wen Yu, Chubing Long, Dong Lin, Feng Lu, Maoling Zhong, Wei Lin, Shupeng Huang, Shuiying Hua, Fuzhou Hua and Xifeng Wang
    Citation: Lipids in Health and Disease 2025 24:295
    Content type: Research Published on:

  47. Metabolic syndrome (MetS) is a worldwide condition that markedly elevates the risk of chronic conditions. The cholesterol, high-density lipoprotein, and glucose (CHG) indices simultaneously reflect various met...

    Authors: Shouxin Wei, Sijia Yu, Chuan Qian, Zhengwen Xu, Yindong Jia and Bo Chen
    Citation: Lipids in Health and Disease 2025 24:294
    Content type: Research Published on:

  48. Cell surface marker (CD) expressions and membrane lipid changes characterise circulating neutrophil transmigration into inflammation sites. Specific CD expressions mandate neutrophil activation. Lipid changes ...

    Authors: A.N. Hunt, R. Cusack, M.P.W. Grocott, G. Koster, A.D. Postle and A. Dushianthan
    Citation: Lipids in Health and Disease 2025 24:293
    Content type: Research Published on:

  49. Preserved Ratio Impaired Spirometry (PRISm) is a condition characterized by a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio ≥ 0.70, yet FEV1 is below 80% of the predicted v...

    Authors: Zhehao Xu, Jia Ding, Ruiyun Liang, Xiwei Huang and Shuangfeng Xie
    Citation: Lipids in Health and Disease 2025 24:292
    Content type: Research Published on:

  50. Diabetic foot ulcers (DFUs) are a severe complication of diabetes, leading to infections, amputations, and reduced quality of life. Ozonated olive oil, combining ozone’s antimicrobial properties with olive oil...

    Authors: Solmaz Vahedi, Masome Rahimi, Tayebeh Sargazi Shad, Yaser Khanchemehr, Khadije Jahangasht Ghoozlu, Somayeh Fallah and Mahboobeh Moradi
    Citation: Lipids in Health and Disease 2025 24:291
    Content type: Research Published on:
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Lipids in Health and Disease

ISSN: 1476-511X