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Insulin resistance (IR)-related indices are validated prognostic markers in metabolic disorders, but have not been applied to preclinical or clinical obesity. This study aimed to investigate the relationship b...
To assess the impact of glycated hemoglobin A1c (HbA1c) in individuals without diabetes and at the extremes of cardiovascular risk factor (CVRF) burden on the incidence of atherosclerotic cardiovascular diseas...
Despite the growing burden of youth-onset type 2 diabetes (Y-T2D), the long-term risk for fatal/non-fatal cardiovascular disease (CVD) in Y-T2D compared to peers is unknown. The International Childhood Cardiov...
This prospective study investigated plaque morphologies based on the underlying culprit lesion pathology in relation to the Atherogenic Index of Plasma (AIP) in patients with acute ST-elevated myocardial infar...
Epicardial adipose tissue is gaining increasing interest as a cardiometabolic imaging biomarker, but its exact role in coronary artery disease is not fully understood. This study aimed to investigate the relat...
This study investigated the relationship between estimated glucose disposal rate (eGDR), aging acceleration (AgeAccel), and mortality in adults diagnosed with cardiovascular-kidney-metabolic (CKM) stages 1 to 4.
It remains unclear whether certain individuals with type 2 diabetes (T2D) derive greater cardiovascular benefit from GLP-1 receptor agonists (GLP-1RAs). Here, we integrate individual-level data from cardiovasc...
Epicardial adipose tissue (EAT) and arterial stiffness are determinants of excess risk of cardiovascular disease in persons with diabetes. This study aimed to evaluate the relationship between both of these co...
Plozasiran (VSA001, ARO-APOC3) is an RNA interference therapy that targets Apolipoprotein C3 (APOC3), a key regulator of lipoprotein metabolism. The study aimed at assessing the safety, tolerability, pharmacok...
This study aimed to elucidate the role of insulin resistance in the progression from non-alcoholic fatty liver disease (NAFLD) to cardiovascular-kidney-metabolic (CKM) diseases, and to explore the potential in...
Degeneration of organ-specific nervous systems precede major clinical conditions such as heart failure, dementia, diabetic retinopathy, and diabetic neuropathy. Glucagon-like peptide-1 receptor (GLP1R) agonist...
Macrophage efferocytosis, essential for the resolution of inflammation and plaque stability in atherosclerosis, is impaired in diabetes. Thrombomodulin (TM) and endothelial protein C receptor (EPCR), key media...
Cardio-Kidney-Metabolic (CKM) syndrome results from the complex interaction of cardiovascular, renal and metabolic comorbidities. Data on the epidemiology and clinical impact of the CKM syndrome in patients wi...
Type 4a myocardial infarction (MI) is a relevant complication in non–ST-segment elevation myocardial infarction (NSTEMI) patients undergoing percutaneous coronary intervention (PCI). While glucometabolic statu...
Cholesterol, high-density lipoprotein, and glucose (CHG) index, an alternative marker of insulin resistance (IR), play a significant role in predicting cardiovascular diseases. However, its prognostic value in...
Cardiogenic shock (CS) represents a life-threatening cardiovascular condition with high mortality rates. Effective glycaemic management plays a critical role in treating CS patients. Glycaemic variability (GV)...
Lipid metabolism plays a pivotal role in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MASLD). However, the effect of the atherogenic index of plasma (AIP)—a novel biomarker for ass...
Deep learning (DL) models can quantify coronary artery calcification using non-gated chest CT scans. However, the prognostic value of a DL-based coronary artery calcium score (DL-CACS) for predicting major adv...
Cancer-associated signaling pathways, particularly the ALK/LTK receptor tyrosine kinases and their ligand ALKAL2, have recently been implicated in chronic inflammation and myocardial remodeling. However, the r...
Epicardial adipose tissue (EAT) plays an important role in the pathogenesis of coronary artery disease (CAD). The association between EAT and obstructive CAD or myocardial ischemia has been established, but it...
The C-Reactive Protein-Triglyceride-Glucose Index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, research on the relationship between CTI changes and stroke is l...
Cardiovascular outcome trials have shown that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce cardiovascular event rates more effectively than placebo and in patients with type 2 diabetes at increa...
Recent evidence suggests that inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), a key enzyme in cholesterol biosynthesis, has beneficial effects on lipid metabolism and blood pressure (BP), b...
Patients with diabetes admitted to emergency care face a higher risk of complications, including prolonged hospital stays, admissions to the intensive care unit and mortality.
The triglyceride-glucose (TyG) index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and estimated glucose disposal rate (eGDR) serve as surrogate marker...
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that interfere with hormone action, and growing evidence suggests that human exposure to certain EDCs may increase the risk of obesity, type 2 diab...
Emerging evidence has highlighted the connection between the Triglyceride-glucose (TyG) index and the development and severity of coronary artery disease. However, the role of the TyG index in predicting adver...
Metabolic disorders, cardiovascular diseases, and chronic kidney diseases are closely interrelated, and the proposal of cardiovascular-kidney-metabolic (CKM) syndrome concept has received extensive attention.T...
Testosterone deficiency is common in men with diabetes. Effects of testosterone therapy on kidney failure and cardiovascular outcomes in diabetic men remain poorly understood. Our aim was to assess whether tes...
Insulin resistance (IR)-related indices are increasingly recognized as important contributors to cardio-renal-metabolic (CRM) diseases. However, most prior studies have focused on isolated outcomes or cross-se...
Type 2 diabetes remains a major global health concern, and plant-based diets (PBD) offer substantial preventive value. The Planetary Health Diet Index (PHDI) captures adherence to an environmentally sustainabl...
This study aims to characterize the prevalence of echocardiographic abnormalities and their associated factors in patients with type 1 diabetes.
Atrial fibrillation (AF) confers a high risk of thromboembolism and cardiovascular events, which persists despite optimal oral anticoagulation (OAC). The non-high-density lipoprotein cholesterol (non-HDL-C) to...
Early mortality prediction in critically ill patients with cardiovascular disease remains challenging. This study aimed to develop and validate an ensemble machine learning (ML) model to predict 30-day mortali...
Insulin resistance (IR) is a key driver of cardiovascular disease. The triglyceride-glucose (TyG) index, derived from fasting triglyceride and glucose levels, has been proposed as a surrogate marker of IR. How...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have demonstrated cardiovascular benefits in randomised controlled trials (RCT). However, the controlled nature of RCTs and the selected trial populations lim...
Combination therapy with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium-glucose co-transporter 2 inhibitors (SGLT2i), and/or finerenone offers a strategy to reduce the risk of adverse cardiovascul...
To investigate the associations between the triglyceride-glucose (TyG) index and its obesity-related derivatives with the risk of incident cardio-renal-metabolic multimorbidity (CRMM) in a Middle Eastern adult...
Stress hyperglycemia ratio (SHR) has emerged as an innovative biomarker for stress-induced hyperglycemia and various disease prognosis, yet its relationship with mortality in patients with type 2 diabetes and ...
The triglyceride-glucose index (TyG) is an emerging marker of metabolic health, yet its association with mortality across different glucose metabolism statuses remains unclear. This study aimed to investigate ...
The triglyceride-glucose (TyG) index, as a measure of insulin resistance, has been confirmed to be associated with adverse clinical outcomes. The new composite indicator, TyG-A body type index (TyG-ABSI), by i...
Combination therapy is gaining attention in type 2 diabetes management due to its potential to reach glycaemic goals within a shorter period. However, the long-term comparative cardiorenal effectiveness of fix...
Type 2 diabetes mellitus (T2DM) patients are at high risk for micro- and macrovascular complications, and cardiovascular (CV) events are a major cause of their increased risk of early death. Despite well-estab...
The original article was published in Cardiovascular Diabetology 2024 23:419
The original article was published in Cardiovascular Diabetology 2025 24:298
The original article was published in Cardiovascular Diabetology 2025 24:210
Insulin resistance (IR) has been recognized as a critical factor in the progression of cardiovascular disease (CVD), yet its association with cardiovascular-kidney-metabolic (CKM) syndrome remains incompletely...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as Empagliflozin, are antidiabetic drugs that reduce glucose levels and have emerged as a promising therapy for patients with heart failure (HF), althoug...
Cardiometabolic multimorbidity (CMM) imposes a progressively severe health burden worldwide. Triglyceride-glucose (TyG) index and waist-to-height ratio (WHtR), as indicators of insulin resistance and central a...
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Cardiovascular Diabetology