Skip to main content
BMC is moving to Springer Nature Link. Visit this journal in its new home.

Articles

Page 1 of 22

  1. See More

    Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment (TME) and have important roles in carcinogenesis and metastasis by facilitating cancer cell proliferation, angiogenesi...

    Authors: Di Wu, Mingzhi Cao, Changgang Yang, Wanshun Li, Deyu Zhang, Shihua Yao, Hong Yu and Gengxi Jiang
    Citation: Biology Direct 2025 20:105
    Content type: Research Published on:

  2. The Salmonella stress response regulator CpxR controls the AcrEF drug efflux pump, which is crucial for key virulence traits such as invasiveness and disruption of the host paracellular pathway. Understanding the...

    Authors: Perumalraja Kirthika, Amal Senevirathne, Vijayakumar Jawalagatti, Suyeon Park, Jun Kwon and John Hwa Lee
    Citation: Biology Direct 2025 20:104
    Content type: Research Published on:

  3. Measles, once considered under control in many high-income countries, has experienced a notable resurgence in recent years due to declining vaccination rates, increased vaccine hesitancy, and gaps in public he...

    Authors: Francesco Branda, Marta Giovanetti, Nicola Petrosillo, Mohamed Mustaf Ahmed, Maria Perra, Daria Sanna, Giancarlo Ceccarelli, Massimo Ciccozzi, Enrico Bucci and Fabio Scarpa
    Citation: Biology Direct 2025 20:103
    Content type: Research Published on:

  5. Advancements in precision oncology have generated increased interest in the prognostic and therapeutic capabilities of transcription factors, among which HMGA1 is significantly correlated with LUAD prognosis. ...

    Authors: Tong Hu, Run Shi, Shiyuan Yin, Tingting Xu, Yangyue Xu, Duo Xu and Yongqian Shu
    Citation: Biology Direct 2025 20:101
    Content type: Research Published on:

  6. Hepatocellular carcinoma (HCC) is significantly influenced by hepatitis B virus (HBV) infection. However, the roles of ferroptosis and ubiquitination modifications in this context remain poorly understood.

    Authors: Wenbiao Chen, Yang Song, Liyang Wang, Feng Xiong and Shenggang Zhang
    Citation: Biology Direct 2025 20:100
    Content type: Research Published on:

  7. Pseudomonas aeruginosa, one of the most prevalent pathogens, is notorious for its multidrug resistance, necessitating novel therapeutic strategies. Phage therapy has emerged as a promising alternative treatment s...

    Authors: Yiming Yang, Wenbo Yan, Yuanli Zhao, Tingting Gao, Yingxin Yang, Linke Cao, Ruixue Tao, Na Liu, Yunlei Yang, Yanrong Liu, Meng Li, Lijun Liu, Yani Zhang and Tietao Wang
    Citation: Biology Direct 2025 20:99
    Content type: Research Published on:

  8. Cholangiocarcinoma (CCA) is an aggressive malignancy with limited treatment options. Despite the approval of chemotherapy and immune checkpoint inhibitors (ICIs) in clinical practice, treatment outcomes remain...

    Authors: Thanpisit Lomphithak, Nattaya Duangthim, Sasiprapa Sonkaew and Siriporn Jitkaew
    Citation: Biology Direct 2025 20:98
    Content type: Research Published on:

  9. Despite therapeutic advances, metastatic melanoma, and particularly brain metastasis (MBM), remains a lethal burden for patients. Existing single-cell studies offer a more detailed view of melanoma and its mic...

    Authors: Konrad Grützmann and Michael Seifert
    Citation: Biology Direct 2025 20:97
    Content type: Research Published on:

  10. Psoriasis is an immune-mediated chronic inflammatory condition characterized by significant neutrophil infiltration in the skin. Given that the spleen is the largest peripheral immune organ in the body, it is ...

    Authors: Feng Shi, Pixia Gong, Shan Huang, Weidong Zhu, Chenxi Shi, Chang Qi, Zhe Lei and Yayun Ding
    Citation: Biology Direct 2025 20:96
    Content type: Research Published on:

  11. Over the last few decades, adipose tissue has attracted increasing attention in the field of regenerative medicine, thanks to discoveries related to its regenerative, anti-inflammatory, and pro-angiogenic prop...

    Authors: Silvia Gandolfi, Elise Lupon, Audrey Varin, Agnes Coste, Brigitte Sallerin, Carla Boyer, Yanis Berkane and Benoit Chaput
    Citation: Biology Direct 2025 20:95
    Content type: Review Published on:

  12. Due to the low response rate and severe side effects, the clinical efficacy of current immunotherapy for patients with colorectal cancer (CRC) remains unsatisfactory. Induction of immunogenic cell death (ICD) ...

    Authors: Wei Wang, Lijiang Zhou, Xinyu Zhang and Zheng Li
    Citation: Biology Direct 2025 20:94
    Content type: Research Published on:

  13. Gallbladder cancer (GBC) is characterised by a desmoplastic microenvironment rich in collagen fibres and extracellular matrix, contributing to increased matrix stiffness. SEMAs are overexpressed in various can...

    Authors: Liankang Sun, Huanhuan Wang, Hanqi Li, Ruida Yang, Xuyuan Dong, Danfeng Dong, Yangwei Fan, Enxiao Li, Hao Wang, Yinying Wu and Yu Shi
    Citation: Biology Direct 2025 20:93
    Content type: Research Published on:

  14. Metabolic alterations are closely associated with the exhaustion and immune deficiency of CD8+ tumor-infiltrating lymphocytes (TILs), while little is known about diffuse large B-cell lymphoma (DLBCL). This study ...

    Authors: Yiming Yang, Yaqi Shu, Zujun Qin, Yi Zeng, Kexin Chen, Xin Liu, Shunhai Jian and Qiqi Zhu
    Citation: Biology Direct 2025 20:92
    Content type: Research Published on:

  15. Globally, HCC is still one of the most common cancers. N6-methyladenosine (m6A) modifications and long-stranded noncoding RNAs (lncRNAs) play key roles in regulating HCC progression. The role of the lncRNA RNF144...

    Authors: Minyu Kong, Wendong Li, Hao Li, Yifan Jing, Min Xu, Yuting He and Wenzhi Guo
    Citation: Biology Direct 2025 20:91
    Content type: Research Published on:

  16. The mucin-degrading bacterium Akkermansia muciniphila has attracted enormous interest for its beneficial effects on human health. However, growing evidence suggests that the Akkermansia genus is populated by seve...

    Authors: Cristian Molteni, Diego Forni, Rachele Cagliani and Manuela Sironi
    Citation: Biology Direct 2025 20:90
    Content type: Research Published on:

  17. Chloride intracellular channels (CLICs) are a family of six evolutionarily conserved proteins with diverse functions. Previously, we identified CLIC2, as the fifth-ranked master regulator associated with diffu...

    Authors: Viviana Longo, Pellegrino Mazzone, Giovanni Calice, Pietro Zoppoli, Giuseppina Di Paola, Giuseppe Cesta, Margherita Luongo, Claudia Sabato, Sabino Russi, Simona Laurino, Tiziana Notarangelo, Giuseppe Patitucci, Chiara Balzamo, Valeria Lucci, Elena Amendola, Giuseppina Amodio…
    Citation: Biology Direct 2025 20:89
    Content type: Research Published on:

  18. Ferroptosis and disulfidptosis are newly discovered forms of regulated cell death that play critical roles in cancer progression, metabolism, and immune evasion. However, their interplay and combined influence...

    Authors: Yifei Zhu, Huixia Huang, Jiayu Chen, Keji Chen, Yanxi Yao, Yaxian Wang, Yuxue Li, Zhibing Qiu, Dawei Li and Ping Wei
    Citation: Biology Direct 2025 20:88
    Content type: Research Published on:

  19. Despite significant advancements in therapeutic approaches for lung cancer, the prognosis of lung squamous cell carcinoma (LUSC) remains suboptimal, underscoring the critical need to identify novel molecular t...

    Authors: Jie Yang, Zhongfei Jia, Juan Li, Chao Jiang, Xin Zhao, Yuxiang Wang, Xiaoguo Ma and Xinjian Xu
    Citation: Biology Direct 2025 20:87
    Content type: Research Published on:

  21. Iron overload and ferroptosis are associated with intestinal ischemia and reperfusion (II/R)-induced acute lung injury (ALI). However, the mechanisms underlying the regulation of iron homeostasis remain unclea...

    Authors: Yunfan Gu, Hui Dong, Yanjun Wang, Beibei Hu, Hong Jiang and Rong Hu
    Citation: Biology Direct 2025 20:85
    Content type: Research Published on:

  22. Doxorubicin (DOX) is a potent chemotherapeutic widely used against various cancers, but its clinical application is limited by DOX-induced cardiotoxicity (DIC). This study explored the cardioprotective potenti...

    Authors: Wan-Tseng Hsu, Shinji Kobuchi, Tung-Chun Russell Chien, I-Chun Chen, Shohei Hamada, Masayuki Tsujimoto, I-Lin Tsai, Yun-Sheng Wong, Kuan-Hsuan Tung and Ying-Zhen He
    Citation: Biology Direct 2025 20:84
    Content type: Research Published on:

  23. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive pulmonary disease characterized by alveolar structural destruction and fibrosis. In recent years, efferocytosis has been recognized as playing a cru...

    Authors: Qian Jin, Yi Kang, Wenwen Jin, Ying Liu, Qian Chen, Jian Liu, Yali Guo and Yuguang Wang
    Citation: Biology Direct 2025 20:83
    Content type: Research Published on:

  24. Renal cell carcinoma (RCC), the most common solid tumor of the kidney, accounts for approximately 3% of all malignancies and has a higher incidence in Western countries. The current frontline treatment for met...

    Authors: Simone Patergnani, Pietro Zampieri, Nicoletta Bianchi, Carmelo Ippolito, Roberta Gafà, Giovanni Lanza, Mariusz R. Wieckowski, Paolo Pinton and Gianluca Aguiari
    Citation: Biology Direct 2025 20:82
    Content type: Research Published on:

  26. Cancer-associated fibroblasts (CAFs) have been reported to play a significant role in the development and metastasis of various tumors; however, research on their role in promoting prostate cancer (PCa) metast...

    Authors: Xiaodong Song, Tiewen Li, Wenhao Zhou, Chengling Feng, Zeng Zhou, Yuanming Chen, Deng Li, Lei Chen, Jing Zhao, Yu Zhang and Bangmin Han
    Citation: Biology Direct 2025 20:80
    Content type: Research Published on:

  27. Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). However, its underlying mechanisms are not fully understood. The purpose of this study was to use bioinformatics and prel...

    Authors: Jialiang Lin, Linjuan Huang, Weiming Li, Haijun Xiao and Mingmang Pan
    Citation: Biology Direct 2025 20:79
    Content type: Research Published on:

  28. Non-small-cell lung cancer (NSCLC) exhibits variable outcomes and remains a leading cause of cancer-related mortality, despite advances in immunotherapy. This study aimed to develop a prognostic model using re...

    Authors: F. V. Moiseenko, M. A. Krasavina, I. R. Agranov, E. V. Artemieva, A. P. Oganesian, A. S. Gabina, M. L. Makarkina, E. O. Elsakova, V. A. Henshtein, N. M. Volkov, V. V. Egorenkov, V. M. Moiseenko, M. Yu. Fedyanin, G. S. Kopeina, B. Zhivotovsky and A. V. Zamaraev
    Citation: Biology Direct 2025 20:78
    Content type: Research Published on:

  29. The prognosis for patients with head and neck cancer (HNC) is usually poor, highlighting the need for new therapeutic strategies. To this end, this study aims to evaluate the antitumor efficacy of a combined t...

    Authors: Valeria Lucarini, Valentina Angiolini, Daniela Nardozi, Monica Benvenuto, Chiara Focaccetti, Patrizia Mancini, Elena Splendiani, Tanja Milena Autilio, Claudio Cortese, Riccardo Bei, Gianluca Nicolai, Camilla Palumbo, Elisabetta Ferretti, Loredana Cifaldi, Roberto Bei and Laura Masuelli
    Citation: Biology Direct 2025 20:77
    Content type: Research Published on:

  31. Ovarian cancer is a complicated and heterogeneous disease. In this study, we investigated the functional significance of the gene TIMM8B, which is differentially expressed in ovarian cancer to better understan...

    Authors: Yue Jia, Jiaqian Liao, Xiangqun Yang, Hongyan Hu, Wentao Zhao, Liufang Zhao, Conghui Ai, Yuanbo Xue, Shufen Tan and Yi Zhang
    Citation: Biology Direct 2025 20:75
    Content type: Research Published on:

  32. Lung adenocarcinoma (LUAD) is one of the common malignant tumors worldwide, and the 5-year survival rate remains unsatisfactory. Reliable prognostic biomarkers are needed to provide references for personalized...

    Authors: Yuqing Dong, Ying Zhang, Haoran Liu, Xintong Jiang, Shuyang Xie and Pingyu Wang
    Citation: Biology Direct 2025 20:74
    Content type: Research Published on:

  33. In sepsis, immunosuppression is commonly observed as lipopolysaccharide (LPS) tolerance in macrophages. Leukocyte immunoglobulin-like receptor B2 (LILRB2) is an inhibitory receptor on immune cells that may pla...

    Authors: Ruojing Bai and Jun Guo
    Citation: Biology Direct 2025 20:73
    Content type: Research Published on:

  34. Pathological complete response (pCR) to neoadjuvant systemic therapy (NAST) is an established prognostic marker in breast cancer (BC). Multimodal deep learning (DL), integrating diverse data sources (radiology...

    Authors: Eriseld Krasniqi, Lorena Filomeno, Teresa Arcuri, Gianluigi Ferretti, Simona Gasparro, Alberto Fulvi, Arianna Roselli, Loretta D’Onofrio, Laura Pizzuti, Maddalena Barba, Marcello Maugeri-Saccà, Claudio Botti, Franco Graziano, Ilaria Puccica, Sonia Cappelli, Fabio Pelle…
    Citation: Biology Direct 2025 20:72
    Content type: Review Published on:

  35. Anti-Müllerian hormone (AMH) levels are frequently elevated in women with polycystic ovary syndrome (PCOS) and serve as a valuable diagnostic biomarker. However, the molecular mechanisms driving AMH overexpres...

    Authors: Yunmei Ke, Jinyan Zheng, Jinman Zhang, Dan Tang, Qin Yang, Han Zhao, Caifen Zhu and Yan Zhang
    Citation: Biology Direct 2025 20:71
    Content type: Research Published on:

  36. Breast cancer is subdivided into four distinct subtypes based on the status of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) as HER2−/HR+, HER2+/HR+, HER2+/HR− and HER2−/HR−. Among th...

    Authors: Aswathy Sivasailam, Kiran S. Kumar, Aparna Geetha Jayaprasad, Shine Varghese Jancy, Ashwathi Harikumar, P. S. Unnikrishnan, K. C. Sivakumar, P. J. Jain Tiffee, Aman Munirpasha Halikar, S. S. Nithin, Prakash R. Pillai, Shivanshu Kumar Tiwari, Vishnu S. Sanjeev, A. V. Surabhi and T. R. Santhoshkumar
    Citation: Biology Direct 2025 20:70
    Content type: Research Published on:

  37. Autophagy is the primary catabolic process responsible for degrading intracellular components and potentially harmful cytosolic entities by delivering them to lysosomes. Notably, this mechanism is crucial for ...

    Authors: Rita Casetti, Fabiola Ciccosanti, Harpreet Kaur Lamsira, Carmela Pinnetti, Valentina Mazzotta, Serena Ciolfi, Alessandra Sacchi, Alessandra Amendola, Giuseppe Ippolito, Mauro Piacentini and Roberta Nardacci
    Citation: Biology Direct 2025 20:69
    Content type: Research Published on:

  38. As members of the nuclear receptor (NR) family of transcription factors, peroxisome proliferator-activated receptors (PPARs) regulate essential cellular processes, including lipid metabolism, glucose uptake, c...

    Authors: Pritha Saha, Palaniyandi Ravanan and Priti Talwar
    Citation: Biology Direct 2025 20:68
    Content type: Research Published on:

  39. Beta-2 microglobulin (β2m) is a small protein that forms the invariant subunit of the Major Histocompatibility Complex I. Monomeric β2m is stable under physiological conditions, however high local concentrations ...

    Authors: Cristina Visentin, Giulia Rizzi, Wen Yin, Mathilde Hotot, Dipambita Roy, Torbjörn Gräslund, Riccardo Capelli and Stefano Ricagno
    Citation: Biology Direct 2025 20:67
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2025 20:86

  40. Single-cell RNA sequencing (scRNA-Seq) technology reveals biological processes and molecular-level genomic information among individual cells. Numerous computational methods, including methods based on graph n...

    Authors: Shuo Wang, Yuanning Liu, Hao Zhang and Zhen Liu
    Citation: Biology Direct 2025 20:66
    Content type: Research Published on:

  41. Sepsis is a life-threatening condition with limited therapeutic options, characterized as excessive systemic inflammation and multiple organ failure. Macrophages play critical roles in sepsis pathogenesis. Alt...

    Authors: Yanjun Zheng, Jingrong Lin, Guoqing Wan, Xuefeng Gu and Jian Ma
    Citation: Biology Direct 2025 20:65
    Content type: Research Published on:

  42. Hepatocellular carcinoma (HCC) is among the deadliest cancers globally. Yes-Associated Protein (YAP), a Hippo pathway effector, crucially regulates cell proliferation and apoptosis. Recent research has implica...

    Authors: Xiaoyong Wei, Long Zou, Yanqing Huang, Chuan Qiu, Guang Cheng, Ye Chen and Jun Rao
    Citation: Biology Direct 2025 20:64
    Content type: Research Published on:

  43. Adaptor proteins play a crucial role in signal transduction by facilitating the assembly of protein complexes at specific subcellular domains. These multifunctional molecules contain multiple binding modules t...

    Authors: Mariana Di Felice, Lucrezia Romana Rolfi, Julian Toso, Valeria Pennacchietti, Eduarda S. Ventura, Angelo Toto, Antonella Tramutola and Stefano Gianni
    Citation: Biology Direct 2025 20:63
    Content type: Research Published on:

  45. Glioma is a malignant tumor associated with poorer prognosis. This study aims to elucidate the mechanism of LINC01018/miR-182-5p/Rab27B axis in PD-L1-mediated CD8+ T cell suppression in the progression of gliomas...

    Authors: Su Hu, Guoshuo Chen, Aiping Luo, Hailin Zhao, Dan Li, Biao Peng, Jike Du and Dongdong Luo
    Citation: Biology Direct 2025 20:61
    Content type: Research Published on:

  46. Protein arginine methyltransferases (Prmts) are essential regulators of various biological processes and have been implicated in the pathogenesis of numerous diseases. However, their role in osteomyelitis rema...

    Authors: Xun Chen, Ning Duan, Wentao Zhang, Tao Song and Fei Cong
    Citation: Biology Direct 2025 20:60
    Content type: Research Published on:

  47. Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme with essential functions in protein trafficking and stability. It is a multidomain protein, with an N-terminal MIT (microtubule interacting and...

    Authors: Aimiliani Konstantinou, Julia K. Varga, Alicia Córdova-Pérez, Leandro Simonetti, Lidia Gomez-Lucas, Ora Schueler-Furman, Norman E. Davey, Yogesh Kulathu and Ylva Ivarsson
    Citation: Biology Direct 2025 20:59
    Content type: Research Published on:

  48. M2 macrophages play a crucial role in the initiation and progression of various tumors, including diffuse large B-cell lymphoma (DLBCL). However, the characterization of M2 macrophage-related genes in DLBCL re...

    Authors: Jiayi Zhang, Zhixiang Jia, Jiahui Zhang, Xiaohui Mu and Limei Ai
    Citation: Biology Direct 2025 20:58
    Content type: Research Published on:

  50. Mitotic catastrophe is well-known as a major pathway of endogenous tumor death, but the prognostic significance of its heterogeneity regarding bladder cancer (BLCA) remains unclear.

    Authors: Haojie Dai, Zijie Yu, You Zhao, Ke Jiang, Zhenyu Hang, Xin Huang, Hongxiang Ma, Li Wang, Zihao Li, Ming Wu, Jun Fan, Weiping Luo, Chao Qin, Weiwen Zhou and Jun Nie
    Citation: Biology Direct 2025 20:56
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • Citation Impact
    Journal Impact Factor: 4.9 (2024)    
    5-year Journal Impact Factor: 5.2 (2024)    
    Source Normalized Impact per Paper (SNIP): 0.878 (2024)    
    SCImago Journal Rank (SJR): 1.199 (2024)

    Speed 
    Submission to first editorial decision (median days): 3
    Submission to acceptance (median days): 80

    Usage 2024
    Downloads: 705,596
    Altmetric mentions: 615

Biology Direct

ISSN: 1745-6150

Contact us