Once considered a metabolic "dead end," lactate is now increasingly recognized as a key mediator of diverse biological functions. Elevated lactate concentrations are associated with many physiological stress and strain responses, suggesting a role in homeostatic control. Recent evidence also indicates that lactate may suppress intrinsic metabolic heat production in mammalian cells. However, the mechanisms underlying this effect-and its implications for cellular responses to heat stress-remain unclear. Here, we: (1) extend the observation of lactate-mediated heat suppression to baker's yeast (Saccharomyces cerevisiae); (2) link this phenomenon to increased mitochondrial Complex II (succinate dehydrogenase) activity; and (3) demonstrate a corresponding reduction in heat-induced cell mortality. These results support an evolving view of lactate, offering new insight into its role in metabolic control and thermoprotection.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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