Descriptive Vs Mechanistic Modeling.pptx

Descriptive Vs Mechanistic Modeling.pptx

• 1.
  11-02-2023 © RR INSTITUTIONS , BANGALORE 1 DESCRIPTIVE VERSUS MECHANISTIC MODELING SUBMITTED BY: SUBMITTED TO: PAWAN DHAMALA PROF. Mr. K MAHALINGAM 2nd Sem , M.Pharm DEPARTMENT OF PHARMACEUTICS COMPUTER AIDED DRUG DEVELOPMENT
• 2.
  11-02-2023 © RR INSTITUTIONS , BANGALORE 2 CONTENT  DESCRIPTIVE MODELING  MECHANISTIC MODELING
• 3.
  • A modelis a description of a system designed to help an observer to understand how it works and to predict its behaviour. Models are typically conceptual, existing as an idea, a computer program or a set of mathematical formulas. • Models are classified into 2 types; • Descriptive model (or empirical model) • Mechanistic model 11-02-2023 © R R INSTITUTIONS , BANGALORE 3 MODELS
• 4.
  DESCRIPTIVE VS MECHANISTICMODEL DESCRIPTIVE MODEL • Descriptive model or empirical model, describes the overall behaviour of the system in question, without making any claim about the nature of the underlying mechanisms that produce this behaviour. • Descriptive model is a generic term for activities that create models by observation and experiment. • Descriptive model operates on a simple logic: the maker observes a close correspondence between the behaviour of the model and that of its referent. • The crafting of this correspondence can be 'empirical' in a wide variety of senses: it may entail a trial-and-error process, may be based on computational approximation to analytic formulae. 11-02-2023 © R R INSTITUTIONS , BANGALORE 4
• 5.
  11-02-2023 © RR INSTITUTIONS , BANGALORE 5 • In Empirical Modelling, the process of construction is an incremental one in which the intermediate products are artefacts that evoke aspects of the intended (and sometimes emerging) referent through live interaction and observation. • Empirical models are based on direct observation, measurement and extensive data records. MECHANISTIC MODEL • A mechanistic model is one where the basic elements of the model have a direct correspondence to the underlying mechanisms in the system being modelled. • A mechanistic model assumes that a complex system can be understood by examining the workings of its individual parts and the manner in which they are coupled.
• 6.
  11-02-2023 © RR INSTITUTIONS , BANGALORE 6 • Mechanistic models typically have a tangible, physical aspect. In that system components are real, solid and visible. • These models are considered as interpretrable or meaningful,but their inherent nature (nonlinearity ,high number of parameters) posess other challenges ,particularly once several sources of noise are also to be adequately modelled. • Mechanistic models are based on an understanding of the behaviour of a system's components.
• 7.
  • Computer Applicationsin Pharmaceutical Research & Development by Sean Ekins • www.slideshare.com • www.google.com 11-02-2023 © R R INSTITUTIONS , BANGALORE 7 References
• 8.
  11-02-2023 © RR INSTITUTIONS , BANGALORE 8