In this Review, the authors describe the mechanisms that mediate mitochondrial sheath formation and its maintenance and function within the mature sperm. They also provide the field with a strong and up-to-date background on current data and hypotheses.

In this Review, the authors describe the pivotal role of taxanes in the treatment of prostate cancer and discuss how mechanisms that confer resistance to taxanes might be exploited to develop more effective therapeutic strategies

In this Perspective, the authors evaluate the current status of prostate-specific membrane antigen (PSMA) ligand-enabled imaging, summarizing novel developments, therapeutic advances and combinatorial approaches. The potential future role of PSMA-based strategies in the future management of prostate cancer is also discussed.

Atypical intraductal proliferation is a prostate biopsy finding with morphological features intermediate between high-grade prostatic intraepithelial neoplasia and intraductal carcinoma. This Review discusses histopathological features, molecular characteristics and clinical outcomes associated with AIP, and highlights the clinical implications of AIP, primarily due to the frequent association of AIP with clinically significant prostate cancer.