Nature Chemistry, Published online: 23 October 2025; doi:10.1038/s41557-025-01976-9
The discovery of benzene two centuries ago marked a turning point in chemistry. From contributing to the development of chemical bonding concepts, to its practical use in the chemical industry, the story of this ring-shaped molecule is a combination of curiosity, science, and human kindness.]]>Nature Chemistry, Published online: 21 October 2025; doi:10.1038/s41557-025-01958-x
Azetidine is a four-membered aza-cycle important in medicinal and organic chemistry. This study describes a mechanism of azetidine amino acid biosynthesis from l-isoleucine or l-valine by two non-haem Fe enzymes, PolF and PolE, in the polyoxin antifungal biosynthetic pathway.]]>Nature Chemistry, Published online: 20 October 2025; doi:10.1038/s41557-025-01970-1
Achieving generality in asymmetric catalysis with highly reactive radicals is a challenge. Now it is shown that a sequential copper-catalysed approach enables the efficient, enantioselective cross-coupling of over 50 diverse radicals, providing unified access to C-, P- and S-chiral products and advancing the asymmetric synthesis of challenging molecular architectures.]]>Nature Chemistry, Published online: 17 October 2025; doi:10.1038/s41557-025-01981-y
Designing enzymatic reaction networks capable of mimicking the complexity of biological information processing is challenging. Now, an in chemico reservoir sensor based on a recursive enzymatic competition network has been designed that can process diverse physical and chemical inputs and perform several information-processing tasks.]]>Nature Chemistry, Published online: 16 October 2025; doi:10.1038/s41557-025-01972-z
The high energetic demand of direct air capture of CO2 challenges its large-scale, industrial application. Now, the use of a photo-base allows for reversible capture of atmospheric CO2 driven by sunlight-induced pH swings.]]>Nature Chemistry, Published online: 16 October 2025; doi:10.1038/s41557-025-01975-w
Achieving enantioselectivity directly through light absorption is a long-standing challenge in photochemistry. Now, light can resolve racemic mixtures at the very moment of photon capture — enabling elegant kinetic resolution via chiral electron donor–acceptor complexes.]]>Nature Chemistry, Published online: 15 October 2025; doi:10.1038/s41557-025-01991-w
Author Correction: Interfacial solvation pre-organizes the transition state of the oxygen evolution reaction]]>Nature Chemistry, Published online: 15 October 2025; doi:10.1038/s41557-025-01992-9
Halogen-substituted silylium ions are among the strongest known Lewis superacids with promising synthetic applications, but their synthesis has not been possible using established methods for generating silicon cations. Now, a general approach to these elusive reactive intermediates is reported, based on the protonation of halosilanes with a Brønsted superacid.]]>