Nature Biomedical Engineering Nature Biomedical Engineering aspires to become the most prominent publishing venue in biomedical engineering by bringing together the most important advances in the discipline, enhancing their visibility by means of opinion and news articles, and providing overviews of the state of the art in each field through topic, disease or technology-focused review articles. http://feeds.nature.com/natbiomedeng/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biomedical Engineering © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]
  • Nature Biomedical Engineering https://www.nature.com/uploads/product/natbiomedeng/rss.png http://feeds.nature.com/natbiomedeng/rss/current <![CDATA[High-throughput evaluation of in vitro CRISPR activities enables optimized large-scale multiplex enrichment of rare variants]]> https://www.nature.com/articles/s41551-025-01535-0 <![CDATA[
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    Nature Biomedical Engineering, Published online: 30 October 2025; doi:10.1038/s41551-025-01535-0

    Cut-seq1, Cut-seq2, DeepCut and CLOVE-seq methods find optimized single-guide RNAs to detect a large number of rare variants in cells.]]> <![CDATA[High-throughput evaluation of in vitro CRISPR activities enables optimized large-scale multiplex enrichment of rare variants]]> Joo Hye YeoSeungho LeeSeungmin KimJoon-Goo MinRamu GopalappaHyeong-Cheol OhHui Kwon KimEun-Ji NamHyongbum Henry Kim doi:10.1038/s41551-025-01535-0 Nature Biomedical Engineering, Published online: 2025-10-30; | doi:10.1038/s41551-025-01535-0 2025-10-30 Nature Biomedical Engineering 10.1038/s41551-025-01535-0 https://www.nature.com/articles/s41551-025-01535-0 <![CDATA[Accelerated sterility testing unlocks safe delivery of life-saving therapies]]> https://www.nature.com/articles/s41551-025-01557-8 <![CDATA[

    Nature Biomedical Engineering, Published online: 29 October 2025; doi:10.1038/s41551-025-01557-8

    A synthetic peptide nanoparticle and microfluidic chip enable sterility testing of cell- and gene-based therapeutics in under 18 hours, bridging a long-standing safety gap for biopharmaceutical products that cannot undergo terminal sterilization and have limited shelf life.]]>     <![CDATA[Accelerated sterility testing unlocks safe delivery of life-saving therapies]]> doi:10.1038/s41551-025-01557-8 Nature Biomedical Engineering, Published online: 2025-10-29; | doi:10.1038/s41551-025-01557-8 2025-10-29 Nature Biomedical Engineering 10.1038/s41551-025-01557-8 https://www.nature.com/articles/s41551-025-01557-8     <![CDATA[Iontronic tip-sensing guidewires]]> https://www.nature.com/articles/s41551-025-01548-9 <![CDATA[

    Nature Biomedical Engineering, Published online: 29 October 2025; doi:10.1038/s41551-025-01548-9

    An iontronic tip-sensing guidewire measures haemodynamic and contact pressure in animal stenosis models and can be integrated with commercial workhorse guidewires.]]>     <![CDATA[Iontronic tip-sensing guidewires]]> Fangyi GuanNingning BaiJia SongNian ZhangJiyu LiYizhou JiangZhiliang HanHanxin WangJunli ShiXi XiaXudong ChenChuan Fei GuoLiu Wang doi:10.1038/s41551-025-01548-9 Nature Biomedical Engineering, Published online: 2025-10-29; | doi:10.1038/s41551-025-01548-9 2025-10-29 Nature Biomedical Engineering 10.1038/s41551-025-01548-9 https://www.nature.com/articles/s41551-025-01548-9     <![CDATA[A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling]]> https://www.nature.com/articles/s41551-025-01538-x <![CDATA[

    Nature Biomedical Engineering, Published online: 29 October 2025; doi:10.1038/s41551-025-01538-x

    A recombinant adeno-associated virus system for restricted gene expression in brain endothelial cells enables cerebrovascular disease modelling.]]>     <![CDATA[A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling]]> Jun-Liszt LiZhanying BiXing-jun ChenTianyue MingBaoshan QiuFengzhi LiZiyan FengDaosheng AiTingting ZhangJiayu WangShuai LinYiping LuZhanjing WangJuan HuangFei ZhaoHu ZhaoYilong WangWenzhi SunWoo-ping Ge doi:10.1038/s41551-025-01538-x Nature Biomedical Engineering, Published online: 2025-10-29; | doi:10.1038/s41551-025-01538-x 2025-10-29 Nature Biomedical Engineering 10.1038/s41551-025-01538-x https://www.nature.com/articles/s41551-025-01538-x     <![CDATA[Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs]]> https://www.nature.com/articles/s41551-025-01545-y <![CDATA[

    Nature Biomedical Engineering, Published online: 28 October 2025; doi:10.1038/s41551-025-01545-y

    Hybrid gRNAs significantly increase targeted editing in the liver while simultaneously reducing unwanted bystander editing in humanized mouse models.]]>     <![CDATA[Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs]]> Madelynn N. WhittakerLauren C. TestaAidan QuigleyDominique L. BrooksSarah A. GrandinetteHooda SaidGarima DwivediIshaan JindalDaphne VolppJulia L. HackerPing QuJosh Zhiyong WangMichael A. LevineRebecca C. Ahrens-NicklasQiaoli LiKiran MusunuruMohamad-Gabriel AlamehWilliam H. PeranteauXiao Wang doi:10.1038/s41551-025-01545-y Nature Biomedical Engineering, Published online: 2025-10-28; | doi:10.1038/s41551-025-01545-y 2025-10-28 Nature Biomedical Engineering 10.1038/s41551-025-01545-y https://www.nature.com/articles/s41551-025-01545-y     <![CDATA[Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy]]> https://www.nature.com/articles/s41551-025-01532-3 <![CDATA[

    Nature Biomedical Engineering, Published online: 28 October 2025; doi:10.1038/s41551-025-01532-3

    A computational method designs receptors called T-SenSERs, which have predictable signalling responses to tumour microenvironment soluble factors and can be co-expressed with conventional CARs in T cells to enhance their therapeutic activity.]]>     <![CDATA[Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy]]> Jan A. RathLucas S. P. RuddenNazila NouraeeTiffany X. Y. QueChristine Von GuntenCynthia PerezFlora BirchYashashvi BhugowonAndreas FueglistalerAisima Chatzi SouleimanPatrick BarthCaroline Arber doi:10.1038/s41551-025-01532-3 Nature Biomedical Engineering, Published online: 2025-10-28; | doi:10.1038/s41551-025-01532-3 2025-10-28 Nature Biomedical Engineering 10.1038/s41551-025-01532-3 https://www.nature.com/articles/s41551-025-01532-3     <![CDATA[Author Correction: Peptide design through binding interface mimicry with PepMimic]]> https://www.nature.com/articles/s41551-025-01570-x <![CDATA[

    Nature Biomedical Engineering, Published online: 27 October 2025; doi:10.1038/s41551-025-01570-x

    Author Correction: Peptide design through binding interface mimicry with PepMimic]]>     <![CDATA[Author Correction: Peptide design through binding interface mimicry with PepMimic]]> Xiangzhe KongRui JiaoHaowei LinRuihan GuoWenbing HuangWei-Ying MaZihua WangYang LiuJianzhu Ma doi:10.1038/s41551-025-01570-x Nature Biomedical Engineering, Published online: 2025-10-27; | doi:10.1038/s41551-025-01570-x 2025-10-27 Nature Biomedical Engineering 10.1038/s41551-025-01570-x https://www.nature.com/articles/s41551-025-01570-x     <![CDATA[Non-covalent assembly of multiple epitopes onto a single nanoparticle]]> https://www.nature.com/articles/s41551-025-01530-5 <![CDATA[

    Nature Biomedical Engineering, Published online: 24 October 2025; doi:10.1038/s41551-025-01530-5

    An engineered nanobody enables modular display of multiple viral epitopes onto a single protein-based nanoparticle, leading to broad-spectrum immunization.]]>     <![CDATA[Non-covalent assembly of multiple epitopes onto a single nanoparticle]]> Liam C. KealyKim L. Good-Jacobson doi:10.1038/s41551-025-01530-5 Nature Biomedical Engineering, Published online: 2025-10-24; | doi:10.1038/s41551-025-01530-5 2025-10-24 Nature Biomedical Engineering 10.1038/s41551-025-01530-5 https://www.nature.com/articles/s41551-025-01530-5