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Breaking the PEG barrier to boost mRNA-LNP therapeutics

Nature Reviews Materials volume 10, pages 799–800 (2025)Cite this article

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mRNA-loaded lipid nanoparticles have gained recognition as a promising therapeutic platform against a wide range of diseases. However, a key component of mRNA-loaded lipid nanoparticles, the polyethylene glycol-conjugated lipid, presents inherent barriers to their therapeutic success. Emerging strategies are now offering potential ways to overcome these limitations.

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Fig. 1: Structures of a typical PEGylated mRNA-LNP and next-generation mRNA-LNPs designed to minimize anti-PEG antibody responses.

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Authors and Affiliations

  1. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Sihan Xiong

  2. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Chuang Liu

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  1. Sihan Xiong
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  2. Chuang Liu
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Correspondence to Chuang Liu.

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Xiong, S., Liu, C. Breaking the PEG barrier to boost mRNA-LNP therapeutics. Nat Rev Mater 10, 799–800 (2025). https://doi.org/10.1038/s41578-025-00852-9

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