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Lipids and Women’s Health

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Edited by:
Catherine Mounier, PhD, University of Quebec at Montreal, Canada
Sherin Ali Nawaito, PhD, University of Quebec at Montreal, Canada

Submission Status: Closed

This collection is no longer accepting submissions.


Lipids in Health and Disease is calling for submissions to our new Collection on "Lipids and Women’s Health". This Collection will explore two thematic areas: Lipids in Reproductive Diseases in Women and Influence of Gender Bias on Recent Lipid Studies.


Image Credit: FatCamera / Getty Images / iStock

  1. Limited studies demonstrated the relationships between first-trimester maternal dyslipidemia and adverse pregnancy-offspring complications. This investigation aimed to probe (1) the relationships of first-trim...

    Authors: Jinnan Liu, Qiangrong Zhai, Jing Wang, Xi Li, Jiayu Chen, Yuanyuan Guo, Fengxia Su, Chang Jiang, Fangyi Ren, Min Li, Guohong Zhang, Gongshu Liu, Ya Gao and Shuo Wang
    Citation: Lipids in Health and Disease 2025 24:335
    Content type: Research Published on:

  2. This study aimed to evaluate the association between mammary intraductal secretions (IDS) and demographic characteristics, clinical manifestations, laboratory indicators and prognosis in patients with non-puer...

    Authors: Wenchao Qu, Jiaye Sun, Shijun Shao, Jiamei Feng, Qingqian Gao, Lu Xie, Xueqing Wu and Hua Wan
    Citation: Lipids in Health and Disease 2025 24:329
    Content type: Research Published on:

  3. Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder associated with reproductive and metabolic dysfunction. Emerging evidence indicates that the lipid accumulation product (LAP) and visceral adi...

    Authors: Mohammadamin Parsaei, Elaheh Karimi, Amirali Barkhordarioon, Mohammadreza Yousefi and Azadeh Tarafdari
    Citation: Lipids in Health and Disease 2025 24:311
    Content type: Review Published on:

  4. Polycystic ovary syndrome (PCOS) is a multifactorial metabolic–endocrine disorder in women of reproductive age in which lipid metabolism disorders and chronic low-grade inflammation reinforce and amplify each ...

    Authors: Wenwen Yang, Nan Pang and Xiaoxia He
    Citation: Lipids in Health and Disease 2025 24:310
    Content type: Review Published on:

  5. This study investigated and compared the abilities of the triglyceride glucose index (TyG) and its correlated factors involving TyG-body mass index (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), and TyG-wais...

    Authors: Weiyan Tu, Rongdi Xu, Dan Wang, Na Luo, Meijing Wu, Yong Zhou and Jing Ning
    Citation: Lipids in Health and Disease 2025 24:218
    Content type: Research Published on:

  6. In postmenopausal women, lower levels of sex hormone-binding globulin (SHBG) have been linked to various metabolic conditions. The association between SHBG levels and the presence of dyslipidemia was investiga...

    Authors: Takahiro Ichikawa, Hiroshi Okada, Masahide Hamaguchi, Megumi Hara, Naoyuki Takashima, Sadao Suzuki, Shiroh Tanoue, Yasufumi Kato, Mako Nagayoshi, Takashi Tamura, Michiaki Fukui and Keitaro Matsuo
    Citation: Lipids in Health and Disease 2025 24:212
    Content type: Research Published on:

  7. The association between metabolic syndrome and female reproductive health has garnered increasing attention; however, the relationship between the Castelli risk index I (CRI-I, total cholesterol/high-density l...

    Authors: WeiJing Yang, XingLong Liu, YuChan Wang, YaLu Fu, ChunE Ren, AiFang Jiang and YuHan Meng
    Citation: Lipids in Health and Disease 2025 24:200
    Content type: Research Published on:

  8. Stress urinary incontinence (SUI) is a common condition affecting the genitourinary system in postmenopausal women. Obesity and dyslipidemia are recognized as significant factors that contribute to the onset o...

    Authors: Ting Yin, Yue He and Huifang Cong
    Citation: Lipids in Health and Disease 2025 24:184
    Content type: Research Published on:

  9. Numerous previous studies have suggested dyslipidemia is possibly linked to endometriosis (EMs). The connection between endometriosis and NHHR remains largely unexplored. Thus, this investigation examined whet...

    Authors: Panpan Jiang, Xingruo Zhang, Haili Huang, Zhuoran Sun, Wenjun Hu and Yuhong Li
    Citation: Lipids in Health and Disease 2025 24:179
    Content type: Research Published on:

  10. Menopause-related cholesterol metabolic disorders pose a global health concern, but the underlying mechanism is unclear. PRKRA was identified as a potential regulator of cholesterol metabolism in an exome-wide...

    Authors: Le Xu, Jian Xu, Wanting Shi, Sa Zhang, Ting Guo and Shien Zou
    Citation: Lipids in Health and Disease 2025 24:171
    Content type: Research Published on:

  11. Previous studies have shown an association between obesity and uterine fibroids (UF). Body roundness index (BRI) is an anthropometric measure associated with obesity. However, the association with UF has not b...

    Authors: Feng Zhang, Min Liu, Shanshan Hu, Ningying Zhou, Danni Wu, Yuqing Zan and Fei Sun
    Citation: Lipids in Health and Disease 2025 24:163
    Content type: Research Published on:

  12. Previous evidence has indicated that insulin resistance may be an early pathological state of preeclampsia (PE). As a novel biomarker, the triglyceride glucose (TyG) index can reflect the level of insulin resi...

    Authors: Qiong Li, Chenyang Zhao, Miao Liu, Meng Li, Ying Zhang and Chaoyan Yue
    Citation: Lipids in Health and Disease 2025 24:152
    Content type: Research Published on:

  13. Hypothyroidism may affect triglyceride-rich lipoprotein (TRL) subfractions and low-density lipoprotein (LDL) and their averaged sizes. The present study aimed to determine whether increases in remnant particle...

    Authors: Adrian Post, Mirthe H. Links, Wouter T. Zandee, Margery A. Connelly, Thera P. Links and Robin P. F. Dullaart
    Citation: Lipids in Health and Disease 2025 24:142
    Content type: Research Published on:

  14. Infertility is a multifaceted condition influenced by metabolic and biochemical factors. Uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) may individually affect reproductive health. The UA-to-H...

    Authors: Yanxiang Kong, Miaoling Lin, Yiman Fu, Baoyi Huang, Mengqi Jin and Lin Ma
    Citation: Lipids in Health and Disease 2025 24:127
    Content type: Research Published on:

  15. Visceral adipose tissue (VAT) is strongly associated with metabolic diseases. Both high-intensity interval training (HIT) and moderate-intensity training (MIT) reduce VAT effectively; however, HIT might mediat...

    Authors: Juanjuan Wang, Shuai Tian, Jinchan Du, Sihao Du, Wei Chen and Yang Liu
    Citation: Lipids in Health and Disease 2025 24:118
    Content type: Research Published on:

  16. Salivary amylase activity (SAA) is recognized as a potential biomarker for metabolic health. Previous studies suggest an association between SAA and insulin sensitivity, but the mechanisms remain unclear. This...

    Authors: Gita Erta, Gita Gersone, Antra Jurka and Peteris Tretjakovs
    Citation: Lipids in Health and Disease 2025 24:98
    Content type: Research Published on:

  18. Trimester-specific reference intervals (TSRIs) for maternal lipid profiles should be determined, and the impact of dyslipidemia on adverse pregnancy outcomes (APOs) should be estimated.

    Authors: Lili Yang, Zhaozhen Liu, Jiayi Chen, Chong Miao, Qingxiu Li, Jinying Chen, Wenjuan Liu, Haiyan Gao, Wei Li, Zhengqin Wu, Bin Sun, Yibing Zhu and Haibo Li
    Citation: Lipids in Health and Disease 2025 24:68
    Content type: Research Published on:

  19. A wealth of evidence indicates that dyslipidemia is associated with endothelial dysfunction, oxidative stress, and inflammation, each of which can impair reproductive function and lead to infertility. The Athe...

    Authors: Zihong Bao, Yanmei Zhang, Ju Zhou and Zhikun Dai
    Citation: Lipids in Health and Disease 2025 24:51
    Content type: Research Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2025 24:104

  20. Maternal glucose and lipid levels are known to influence fetal growth. However, data on how maternal lipid profiles affect birth size in women with gestational diabetes (GDM) compared with those without GDM ar...

    Authors: Jing Peng, Li Zhang, Jing Jin, Huazhang Miao, Guocheng Liu and Yong Guo
    Citation: Lipids in Health and Disease 2025 24:43
    Content type: Research Published on:

  21. Prior research indicates a potential link between dyslipidemia and endometriosis (EMs). However, the relationship between remnant cholesterol (RC) and EMs has not been thoroughly investigated. Consequently, lo...

    Authors: Zeru Chen, Ruixuan Li, Jiajie Guo, Xiaorong Ye, Yang Zhou and Mingzhu Cao
    Citation: Lipids in Health and Disease 2025 24:2
    Content type: Research Published on:

  22. Postmenopausal women are more susceptible to stress urinary incontinence (SUI), and insulin resistance (IR) is closely related to SUI. The triglyceride-glucose (TyG) index is an efficient metric for assessing ...

    Authors: Xueping Huang, Wen Hu and Limei Li
    Citation: Lipids in Health and Disease 2024 23:419
    Content type: Research Published on:

  23. Resolvins, which are divided into series D (RvD) and E (RvE), originate from omega-3 fatty acids, DHA and EPA and were recently found to be involved in the modulation of inflammation in some tumors, including ...

    Authors: Alessio Molfino, Giovanni Imbimbo, Gerardo Salerno, Luana Lionetto, Alessandro De Luca, Maria Ludovica Costanzo, Maurizio Simmaco, Maurizio Muscaritoli and Maria Ida Amabile
    Citation: Lipids in Health and Disease 2024 23:396
    Content type: Research Published on:

  24. Some research indicates that unsaturated fatty acids (UFAs) in the diet could enhance reproductive outcomes in infertile women. However, other research holds different views, possibly due to differences in the...

    Authors: Lifang Wang, Xue Bai, Limei Zhao, Xiaodong Li, Fangxiang Mu, Chunyan Liu and Qiong Xie
    Citation: Lipids in Health and Disease 2024 23:377
    Content type: Research Published on:

  25. Glycated Albumin (GA) and atherogenic index of plasma (AIP) are two important biomarkers that respectively reflect lipid and glucose levels. Previous research has revealed their roles in cardiovascular disease...

    Authors: Xunxun Feng, Yang Liu, Jiaqi Yang, Shiwei Yang, Zhiming Zhou, Yujie Zhou and Qianyun Guo
    Citation: Lipids in Health and Disease 2024 23:352
    Content type: Research Published on:

  26. Gestational diabetes mellitus (GDM) is a common complication of mid–to-late pregnancy. Here, we constructed a predictive model for GDM based on a combination of clinical characteristics and relevant serum mark...

    Authors: Hui Wang, Qian Li, Haiwei Wang and Wenxia Song
    Citation: Lipids in Health and Disease 2024 23:349
    Content type: Research Published on:

  27. Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship between levels of specific lipids and facial aging v...

    Authors: Mingjian Zhao, Zhanchen He, Lukuan Liu, Yichen Wang, LinQi Gao, Yuxuan Shang and Mengru Zhu
    Citation: Lipids in Health and Disease 2024 23:342
    Content type: Research Published on:

  28. Endometriosis is intricately linked to metabolic health. The Cardiometabolic Index (CMI), a novel and readily accessible indicator, is utilized to evaluate metabolic status. This study seeks to investigate the...

    Authors: Jiameng Wang, Boyu Wang, Ting Liu, Jingying Shang, Xumeng Gu, Tianchan Zhang and Huifang Cong
    Citation: Lipids in Health and Disease 2024 23:328
    Content type: Research Published on:

  29. As one of the main pathogenic factors of cardiovascular and cerebrovascular diseases, the incidence of metabolic diseases such as adiposity and metabolic dysfunction-associated steatotic liver disease (MASLD) ...

    Authors: Dihong Gong, Juanhong Lei, Xudong He, Junjie Hao, Fan Zhang, Xinya Huang, Wen Gu, Xingxin Yang and Jie Yu
    Citation: Lipids in Health and Disease 2024 23:322
    Content type: Review Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2024 23:382

  30. Obesity stands as an essential factor contributing to infertility in women. Early identification of obese individuals leads to favorable results for female infertility. The objective of this research is to ass...

    Authors: Mingqin Kuang, Ying Yu and Shanyang He
    Citation: Lipids in Health and Disease 2024 23:314
    Content type: Research Published on:

  31. Given the established link between obesity and hyperuricemia (HUA), the research want to investigate the relationship between different obesity indices and HUA, and further analyze which obesity index can bett...

    Authors: Yuntong Liu, Wei Zhao, Xuhan Liu, Haodong Jiang, Yixia Wu, Lan Luo and Zhengnan Gao
    Citation: Lipids in Health and Disease 2024 23:305
    Content type: Research Published on:

  32. Remnant cholesterol (RC) exert a significant influence on atherosclerotic cardiovascular disease development. However, the prognostic implications of RC in menopausal women received percutaneous coronary inter...

    Authors: Xunxun Feng, Yang Liu, Jiaqi Yang, Zhiming Zhou, Shiwei Yang, Yujie Zhou and Qianyun Guo
    Citation: Lipids in Health and Disease 2024 23:276
    Content type: Research Published on:

  33. Having positive psychological well-being has been associated with serum high-density lipoprotein cholesterol (HDLC), but no longitudinal study to date has examined the association between Ikigai and serum HDLC...

    Authors: Shiori Ikeda, Ai Ikeda, Kazumasa Yamagishi, Isao Muraki, Takumi Matsumura, Tomomi Kihara, Tomoko Sankai, Midori Takada, Takeo Okada, Masahiko Kiyama, Hironori Imano, Hiroyasu Iso and Takeshi Tanigawa
    Citation: Lipids in Health and Disease 2024 23:270
    Content type: Research Published on:

  34. Changes in the oxidative stress and lipid metabolism (OSLM) pathways play important roles in polycystic ovarian syndrome (PCOS) pathogenesis and development. Consequently, a systematic analysis of genes relate...

    Authors: Cuiyu Tan, Shuqiang Huang, Liying Xu, Tongtong Zhang, Xiaojun Yuan, Zhihong Li, Miaoqi Chen, Cairong Chen and Qiuxia Yan
    Citation: Lipids in Health and Disease 2024 23:248
    Content type: Research Published on:

  35. Visceral fat accumulation and obesity-induced chronic inflammation have been proposed as early markers for multiple disease states, especially in women. Nevertheless, the potential impact of fat distribution o...

    Authors: Siqi Wu, Ying Teng, Yuanqi Lan, Maoyang Wang, Tianhua Zhang, Dali Wang and Fang Qi
    Citation: Lipids in Health and Disease 2024 23:235
    Content type: Research Published on:

About the collection

In this Collection we aim to explore two thematic areas: Lipids in Reproductive Diseases in Women and Influence of Gender Bias on Recent Lipid Studies.

Lipids in Reproductive Diseases in Women

Lipids play a crucial role in the pathophysiology of reproductive diseases in women, serving as key modulators of hormonal balance, inflammation and cellular signaling pathways. This Collection will investigate the complex relationship between lipids and reproductive health, examining their impact on conditions such as polycystic ovary syndrome (PCOS), endometriosis, and infertility. Recent research has provided valuable insights into how lipid metabolism affects women’s reproductive physiology, from dyslipidemia-associated comorbidities to the role of lipid mediators in modulating reproductive tissue function. This Collection aims to pave the way for novel therapeutic intervention and personalized approaches to women’s health.

Influence of Gender Bias on Recent Lipid Studies

Recent advancement in lipids and women’s health research have shed light on the intricate interplay between lipid metabolism and various disease states. However, the influence of gender bias continues to shape lipid research in women’s health. This Collection aims to dissect the impact of gender bias on recent lipid studies. From underrepresentation of women in lipid research cohorts to gender disparities in the evaluation and management of lipid-related diseases, such as cardiovascular disease and metabolic syndrome, sexual bias poses a threat to our understanding of lipid metabolism and its implications for women’s health. By promoting a more equitable and inclusive approach to lipid research, this edition aims to improve our ability to prevent, diagnose, and treat lipid-related diseases in women. 

We welcome articles including original articles, systematic reviews, and meta-analyses on these two thematic areas.

Keywords: lipid metabolism, women’s health, reproductive diseases, lipid-related diseases

The topics of interest include but not limited to:

• Understanding the role of lipids in reproductive health and disease in women.
• Understanding of sex-specific differences in lipid-related diseases pathogenesis.
• The development of novel therapeutic interventions targeting lipid metabolism and signaling pathways for the treatment of reproductive diseases and lipid-related diseases and associated comorbidities in women.
• Lipidomics and metabolomics approaches in understanding reproductive diseases in women.
• Epigenetic regulation of lipid metabolism in reproductive diseases.
• Role of gut microbiota and its metabolites in modulating lipid metabolism in metabolic and reproductive function.
• Impact of dietary lipids on metabolic and reproductive health outcomes in women.

Questions to be answered:

• How do lipids contribute to the pathophysiology of reproductive diseases in women?
• What are the mechanisms by which dyslipidemia affects hormonal balance, inflammation, and cellular signaling pathways in women's reproductive health?
• How do lipid mediators modulate the function of reproductive tissues, and what implications does this have for disease development and progression?
• What sex-specific differences exist in the pathogenesis of lipid-related diseases, and how do these differences influence disease presentation, diagnosis, and treatment in women?

Submission Guidelines

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Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Lipids and Women’s Health" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.