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Houston Methodist's Articles

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NPC1 as a novel therapeutic target for induction of pyroptosis in cancers

Authors: Chuanchao Zhang, Qiang Wang, Pan Su, Jianfei Qian, Qi Guo, Wei Wu, Rui Duan, Yufei Zhang, Youli Zu, Ling Zhong, Liuling Xiao and Qing Yi

Citation: Biomarker Research 2025 13:115

Content type: Research Published on: 26 September 2025
High-grade glioma with pleomorphic and pseudopapillary features: a single-institution series of three cases

Authors: Eric A. Goethe, Rasha Alfattal, Subhiksha Srinivasan, Pushan Dasgupta, Vinay Puduvalli, Shiao-Pei Weathers, Leomar Y. Ballester, Jeffrey S. Weinberg, Sujit Prabhu, Sherise D. Ferguson and Maria A. Gubbiotti

Citation: Acta Neuropathologica Communications 2025 13:176

Content type: Research Published on: 18 August 2025
Therapeutic landscape of ovarian cancer: recent advances and emerging therapies

Authors: Ling Wang, Qun Zhang, Xue Wang, Zixuan Dong, Shanshan Liu, Qi Wang, Zhiqiang Zhang and Junji Xing

Citation: Biomarker Research 2025 13:103

Content type: Review Published on: 12 August 2025
Comparative outcomes of human acellular dermal matrices in breast reconstruction: a systematic review and meta-analysis framework

Authors: Yousef Tanas, Grace Gasper, Julie Tanas, Sarya Swed and Gioacchino De Sario Velasquez

Citation: Systematic Reviews 2025 14:157

Content type: Protocol Published on: 30 July 2025
Low-dose interleukin-2 in patients with mild to moderate Alzheimer’s disease: a randomized clinical trial

Authors: Alireza Faridar, Nazaret Gamez, Daling Li, Yanling Wang, Reena Boradia, Aaron D. Thome, Weihua Zhao, David R. Beers, Jason R. Thonhoff, Mohammad O. Nakawah, Gustavo C. Román, John J. Volpi, Jon B. Toledo, Michael George, Charles S. Davis, Belen Pascual…

Citation: Alzheimer's Research & Therapy 2025 17:146

Content type: Research Published on: 4 July 2025
COVID-19 infection history as a risk factor for early pregnancy loss: results from the electronic health record-based Southeast Texas COVID and Pregnancy Cohort Study

Authors: Micaela N. Sandoval, Michelle R. Klawans, MacKinsey A. Bach, Jennifer Mikhail, Edward A. Graviss, Tru Cao, Jacqueline G. Parchem, Junaid Husain and Eric Boerwinkle

Citation: BMC Medicine 2025 23:274

Content type: Research Published on: 9 May 2025
Optimizing mesenchymal stem cell therapy: from isolation to GMP-compliant expansion for clinical application

Authors: Michael E. Williams, Federica Banche Niclot, Sara Rota, Jaesang Lim, Janaina Machado, Ricardo de Azevedo, Katia Castillo, Samuel Adebiyi, Ranga Sreenivasan, Daniel Kota, Patrick C. Mcculloch and Francesca Taraballi

Citation: BMC Molecular and Cell Biology 2025 26:15

Content type: Research Published on: 6 May 2025
Probiotic treatment induces sex-dependent neuroprotection and gut microbiome shifts after traumatic brain injury

Authors: Morgan Holcomb, Austin G. Marshall, Hannah Flinn, Mariana Lozano-Cavazos, Sirena Soriano, Fernando Gomez-Pinilla, Todd J. Treangen and Sonia Villapol

Citation: Journal of Neuroinflammation 2025 22:114

Content type: Research Published on: 20 April 2025
Crosstalk between metabolism and epigenetics during macrophage polarization

Authors: Kangling Zhang and Chinnaswamy Jagannath

Citation: Epigenetics & Chromatin 2025 18:16

Content type: Review Published on: 29 March 2025
Gut Microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients

Authors: Paula L. Scalzo, Austin G. Marshall, Sirena Soriano, Kristen Curry, Mario Dulay, Timea Hodics, Eamonn M. M. Quigley, Todd J. Treangen, María M. Piskorz and Sonia Villapol

Citation: Journal of Translational Medicine 2025 23:327

Content type: Research Published on: 14 March 2025
Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence

Authors: Joy Mitra, Manohar Kodavati, Prakash Dharmalingam, Erika N. Guerrero, K. S. Rao, Ralph M. Garruto and Muralidhar L. Hegde

Citation: Acta Neuropathologica Communications 2025 13:54

Content type: Research Published on: 8 March 2025
Cognitive decline profiles associated with lewy pathology in the context of Alzheimer’s disease neuropathologic change

Authors: Jon B. Toledo, David P. Salmon, Melissa J. Armstrong and Douglas Galasko

Citation: Alzheimer's Research & Therapy 2024 16:270

Content type: Research Published on: 20 December 2024
Cardiovascular disease burden in the North Africa and Middle East region: an analysis of the global burden of disease study 1990–2021

Authors: Hamidreza Soleimani, Ali Nasrollahizadeh, Amir Nasrollahizadeh, Iman Razeghian, Mohammad Mahdi Molaei, Diaa Hakim, Khurram Nasir, Sadeer Al-Kindi and Kaveh Hosseini

Citation: BMC Cardiovascular Disorders 2024 24:712

Content type: Research Published on: 19 December 2024
The LILRB family in hematologic malignancies: prognostic associations, mechanistic considerations, and therapeutic implications

Authors: Alan Hodges, Rachel Dubuque, Shu-Hsia Chen and Ping-Ying Pan

Citation: Biomarker Research 2024 12:159

Content type: Review Published on: 19 December 2024
Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction

Authors: Kang-Chieh Huang, Cátia Gomes, Yukihiro Shiga, Nicolas Belforte, Kirstin B. VanderWall, Sailee S. Lavekar, Clarisse M. Fligor, Jade Harkin, Shelby M. Hetzer, Shruti V. Patil, Adriana Di Polo and Jason S. Meyer

Citation: Acta Neuropathologica Communications 2024 12:164

Content type: Research Published on: 18 October 2024
Intracellular delivery of antiviral shRNA using penetratin-based complexes effectively inhibits respiratory syncytial virus replication and host cell apoptosis

Authors: Faezeh Faghirabadi, Haniyeh Abuei, Mohammad Hossein Malekzadeh, Anahita Mojiri and Ali Farhadi

Citation: Virology Journal 2024 21:235

Content type: Research Published on: 30 September 2024
Adipocyte derived exosomes promote cell invasion and challenge paclitaxel efficacy in ovarian cancer

Authors: Michael Ellis Williams, David Howard, Claire Donnelly, Fereshteh Izadi, Jezabel Garcia Parra, Megan Pugh, Kadie Edwards, Kerryn Lutchman-Sigh, Sadie Jones, Lavinia Margarit, Lewis Francis, R. Steven Conlan, Francesca Taraballi and Deyarina Gonzalez

Citation: Cell Communication and Signaling 2024 22:443

Content type: Research Published on: 16 September 2024
Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer

Authors: Prashant Dogra, Vrushaly Shinglot, Javier Ruiz-Ramírez, Joseph Cave, Joseph D. Butner, Carmine Schiavone, Dan G. Duda, Ahmed O. Kaseb, Caroline Chung, Eugene J. Koay, Vittorio Cristini, Bulent Ozpolat, George A. Calin and Zhihui Wang

Citation: Molecular Cancer 2024 23:156

Content type: Research Published on: 2 August 2024
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner

Authors: Vincent E. Provasek, Manohar Kodavati, Brandon Kim, Joy Mitra and Muralidhar L. Hegde

Citation: Molecular Brain 2024 17:32

Content type: Micro report Published on: 5 June 2024
Past, present, and future of sustainable intensive care: narrative review and a large hospital system experience

Authors: Faisal N. Masud, Farzan Sasangohar, Iqbal Ratnani, Sahar Fatima, Marco Antonio Hernandez, Teal Riley, Jason Fischer, Atiya Dhala, Megan E. Gooch, Konya Keeling-Johnson, Jukrin Moon and Jean-Louis Vincent

Citation: Critical Care 2024 28:154

Content type: Perspective Published on: 9 May 2024