Ionis Pharmaceuticals

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Ionis Pharmaceuticals is exploiting its expertise in RNA to discover and develop novel human therapeutic drugs for patients. The company is also developing a biosensor to identify infectious organisms.

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Ionis Pharmaceuticals's Articles

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Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress

Authors: Emma Andersson, Xiangdong Gongye, Emmelie Cansby, Jingjing Zhang, Mara Caputo, Bernice Asiedu, Viktor Garellick, Sheri Booten, Sue Murray, Ferran Font-Gironès, Johan Ruud, Dan Emil Lind, Manoj Amrutkar, Brian W. Howell, Ingrid Wernstedt Asterholm and Margit Mahlapuu

Citation: BMC Medicine 2025 23:518

Content type: Research Published on: 22 September 2025
Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans

Authors: Ewa Karwatowska-Prokopczuk, Anastasia Lesogor, Jing-He Yan, Angelika Hoenlinger, Alison Margolskee, Lu Li and Sotirios Tsimikas

Citation: Lipids in Health and Disease 2024 23:329

Content type: Research Published on: 3 October 2024
Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

Authors: Roger M. Lane, Taher Darreh-Shori, Candice Junge, Dan Li, Qingqing Yang, Amanda L. Edwards, Danielle L. Graham, Katrina Moore and Catherine J. Mummery

Citation: BMC Neurology 2024 24:116

Content type: Research Published on: 9 April 2024
Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Authors: Yun Hu, Alexey Revenko, Hampartsoum Barsoumian, Genevieve Bertolet, Natalie Wall Fowlkes, Hadi Maazi, Morgan Maureen Green, Kewen He, Duygu Sezen, Tiffany A. Voss, Claudia S Kettlun Leyton, Fatemeh Masrorpour, Zahid Rafiq, Nahum Puebla-Osorio, Carola Leuschner, Robert MacLeod…

Citation: Journal of Experimental & Clinical Cancer Research 2024 43:70

Content type: Research Published on: 6 March 2024
Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

Authors: Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu and Seiko Ikezu

Citation: Acta Neuropathologica Communications 2023 11:166

Content type: Research Published on: 19 October 2023
Symptoms and impacts of familial chylomicronemia syndrome: a qualitative study of the patient experience

Authors: Kate Williams, Georgina Tickler, Pedro Valdivielso, Jordi Alonso, Montserrat Vera-Llonch, Laia Cubells and Sarah Acaster

Citation: Orphanet Journal of Rare Diseases 2023 18:316

Content type: Research Published on: 11 October 2023
The impact of inotersen on Neuropathy Impairment Score in patients with hereditary transthyretin amyloidosis with polyneuropathy

Authors: Aaron Yarlas, Andrew Lovley, Duncan Brown, Montserrat Vera-Llonch, Sami Khella and Chafic Karam

Citation: BMC Neurology 2023 23:108

Content type: Research Published on: 17 March 2023
Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

Authors: Daniel A. Rauch, Sydney L. Olson, John C. Harding, Hemalatha Sundaramoorthi, Youngsoo Kim, Tianyuan Zhou, A. Robert MacLeod, Grant Challen and Lee Ratner

Citation: Retrovirology 2020 17:27

Content type: Research Published on: 28 August 2020
Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

Authors: Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze and Ajay Verma

Citation: Journal of Translational Medicine 2020 18:309

Content type: Research Published on: 8 August 2020
A modular analysis of microglia gene expression, insights into the aged phenotype

Authors: Christine E. Cho, Sagar S. Damle, Edward V. Wancewicz, Swagatam Mukhopadhyay, Christopher E. Hart, Curt Mazur, Eric E. Swayze and Fredrik Kamme

Citation: BMC Genomics 2019 20:164

Content type: Research article Published on: 28 February 2019
STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

Authors: Matthew J. Reilley, Patricia McCoon, Carl Cook, Paul Lyne, Razelle Kurzrock, Youngsoo Kim, Richard Woessner, Anas Younes, John Nemunaitis, Nathan Fowler, Michael Curran, Qinying Liu, Tianyuan Zhou, Joanna Schmidt, Minji Jo, Samantha J. Lee…

Citation: Journal for ImmunoTherapy of Cancer 2018 6:119

Content type: Research article Published on: 16 November 2018
Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

Authors: Lulu Huang, Audrey Low, Sagar S. Damle, Melissa M. Keenan, Steven Kuntz, Susan F. Murray, Brett P. Monia and Shuling Guo

Citation: Genome Biology 2018 19:4

Content type: Research Published on: 15 January 2018
The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

Authors: Oskar Marín-Béjar, Aina M. Mas, Jovanna González, Dannys Martinez, Alejandro Athie, Xabier Morales, Mikel Galduroz, Ivan Raimondi, Elena Grossi, Shuling Guo, Ana Rouzaut, Igor Ulitsky and Maite Huarte

Citation: Genome Biology 2017 18:202

Content type: Research Published on: 27 October 2017
Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate

Authors: Noriko Satake, Connie Duong, Sakiko Yoshida, Michael Oestergaard, Cathy Chen, Rachael Peralta, Shuling Guo, Punit P Seth, Yueju Li, Laurel Beckett, Jong Chung, Jan Nolta, Nitin Nitin and Joseph M Tuscano

Citation: Molecular Medicine 2016 22:2201632

Content type: Research Article Published on: 22 July 2016
Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis

Authors: Marshelle S Warren, Steven G Hughes, Walter Singleton, Mason Yamashita and Mark C Genovese

Citation: Arthritis Research & Therapy 2015 17:80

Content type: Research article Published on: 19 March 2015
PintlincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

Authors: Oskar Marín-Béjar, Francesco P Marchese, Alejandro Athie, Yolanda Sánchez, Jovanna González, Victor Segura, Lulu Huang, Isabel Moreno, Alfons Navarro, Mariano Monzó, Jesús García-Foncillas, John L Rinn, Shuling Guo and Maite Huarte

Citation: Genome Biology 2013 14:R104

Content type: Research Published on: 26 September 2013
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

Authors: Janine Krüger, Manuela Trappiel, Markus Dagnell, Philipp Stawowy, Heike Meyborg, Christian Böhm, Sanjay Bhanot, Arne Östman, Ulrich Kintscher and Kai Kappert

Citation: Cell Communication and Signaling 2013 11:49

Content type: Research Published on: 26 July 2013
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

Authors: Sang-il Lee, David L Boyle, Andres Berdeja and Gary S Firestein

Citation: Arthritis Research & Therapy 2012 14:R38

Content type: Research article Published on: 21 February 2012
Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

Authors: Que Liu, Christen Anderson, Anatoly Broyde, Clara Polizzi, Rayne Fernandez, Alain Baron and David G Parkes

Citation: Cardiovascular Diabetology 2010 9:76

Content type: Original investigation Published on: 16 November 2010
The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats

Authors: Que Liu, Lisa Adams, Anatoly Broyde, Rayne Fernandez, Alain D Baron and David G Parkes

Citation: Cardiovascular Diabetology 2010 9:32

Content type: Original investigation Published on: 3 August 2010

Ionis Pharmaceuticals

Ionis Pharmaceuticals's Articles

Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress

Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

Symptoms and impacts of familial chylomicronemia syndrome: a qualitative study of the patient experience

The impact of inotersen on Neuropathy Impairment Score in patients with hereditary transthyretin amyloidosis with polyneuropathy

Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

A modular analysis of microglia gene expression, insights into the aged phenotype

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate

Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis

PintlincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats