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. 1998 Oct;21(4):717-26.
doi: 10.1016/s0896-6273(00)80589-9.

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors

J C Tu  1 , B Xiao, J P Yuan, A A Lanahan, K Leoffert, M Li, D J Linden, P F Worley
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Free article

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors

J C Tu et al. Neuron. 1998 Oct.
Free article

Abstract

Group I metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich "Homer ligand" (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the IEG form of Homer, which lacks the ability to cross-link, modulates mGluR-induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.

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