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Review
. 1997 Dec 1;7(12):R759-62.
doi: 10.1016/s0960-9822(06)00398-8.

Hedgehog signalling: Ci complex cuts and clasps

D Kalderon  1
Affiliations
Free article
Review

Hedgehog signalling: Ci complex cuts and clasps

D Kalderon. Curr Biol. .
Free article

Abstract

Hedgehog (Hh) signalling in Drosophila inhibits partial proteolysis of the transcription factor Cubitus interruptus (Ci), and the ability of a complex containing Ci and the kinesin-related protein Costal-2 to bind microtubules. These changes are proposed to turn Ci from a repressor to an activator of Hh-target genes.

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