Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Aug;12(10):943-52.
doi: 10.1002/(sici)1097-0061(199608)12:10<943::aid-yea997>3.0.co;2-3.

Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth

A A Duina  1 , J A Marsh, R F Gaber
Affiliations

Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth

A A Duina et al. Yeast. 1996 Aug.

Abstract

We report the analysis of two Saccharomyces cerevisiae cyclophilins, Cpr6 and Cpr7, identified by their ability to interact in vivo with the transcriptional regulator Rpd3. Both cyclophilins have an extended carboxy-terminal region containing a three-unit tetratricopeptide repeat (TPR) motif and share significant amino acid identity with the mammalian cyclophilin CyP-40. Neither CPR6 nor CPR7 is essential but deletion of CPR7 results in a significant impairment of the rate of cell division. This is the first demonstration that a member of the cyclophilin family is required for normal cell growth.

PubMed Disclaimer

Publication types

MeSH terms

Associated data

LinkOut - more resources