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. 1996 Nov 1;274(5288):784-7.
doi: 10.1126/science.274.5288.784.

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

C Y Wang  1 , M W Mayo, A S Baldwin Jr
Affiliations

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

C Y Wang et al. Science. .

Abstract

Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-kappaB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-kappaB nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-kappaB. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-kappaB, and have potential for improvement of the efficacy of cancer therapies.

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