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. 1993 Sep 5;233(1):183-8.
doi: 10.1006/jmbi.1993.1497.

A Saccharomyces cerevisiae cyclophilin resident in the endoplasmic reticulum

G Frigerio  1 , H R Pelham
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A Saccharomyces cerevisiae cyclophilin resident in the endoplasmic reticulum

G Frigerio et al. J Mol Biol. .

Abstract

Cyclophilins are cyclosporin A sensitive peptidyl-prolyl cis-trans isomerases found in the cytoplasm of a wide range of species from Escherichia coli to man. Cyclophilin homologues are translocated into mitochondria, the endoplasmic reticulum and the bacterial periplasmic space. Here, the nucleotide sequence of a non-essential fifth Saccharomyces cerevisiae cyclophilin homologue encoded by chromosome XII is presented. As expected from its hydrophobic signal sequence and a hydrophilic carboxy terminus ending in the tetrapeptide HDEL, epitope-tagged cyclophilin D was found associated with the endoplasmic reticulum.

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