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. 1993 Dec 8;134(2):295-8.
doi: 10.1016/0378-1119(93)90110-o.

A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

H Schwarz  1 , J Tuckwell, M Lotz
Affiliations

A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

H Schwarz et al. Gene. .

Abstract

A 1.4-kb full-length cDNA was isolated from a library constructed from activated human T-cell leukemia virus type 1-transformed human T-lymphocytes. Sequence analysis identified this cDNA as a new member of the human nerve-growth-factor receptor/tumor-necrosis-factor receptor family and as the potential human homologue of the murine sequence, 4-1BB. The gene encodes three cysteine-rich motifs in the extracellular domain which are characteristic of this receptor family, a transmembrane region and a short N-terminal cytoplasmic portion which contains potential phosphorylation sites.

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