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. 1994 Jul 25;652(1):169-73.
doi: 10.1016/0006-8993(94)90334-4.

Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line

J B Davis  1 , P Maher
Affiliations

Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line

J B Davis et al. Brain Res. .

Abstract

A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity afforded by TPA. The data suggest that protein kinase C activation blocks an early step in the cytotoxic pathway.

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