Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Dec;69(12):8076-8.
doi: 10.1128/JVI.69.12.8076-8078.1995.

The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein

H H Chen  1 , W P Kong, R P Roos
Affiliations

The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein

H H Chen et al. J Virol. 1995 Dec.

Abstract

The leader (L) peptide is located in the amino-terminal part of the polyprotein of members of the Cardiovirus (which includes Theiler's murine encephalomyelitis virus) and Aphthovirus genera of picornaviruses. Although the function of L is unknown, strain DA of Theiler's murine encephalomyelitis virus with a mutation of L produces a cell-specific restricted infection. We now report that the DA L peptide is a metalloprotein and that zinc binds to a Cys-His motif that is conserved among cardioviruses.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4195-9 - PubMed
    1. Virology. 1988 May;164(1):245-55 - PubMed
    1. J Virol. 1988 Nov;62(11):4407-9 - PubMed
    1. J Virol. 1989 Mar;63(3):1404-7 - PubMed
    1. Virology. 1989 Nov;173(1):35-45 - PubMed

Publication types

MeSH terms

LinkOut - more resources