Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Sep;311(5981):33-8.
doi: 10.1038/311033a0.

Sequence requirements for nuclear location of simian virus 40 large-T antigen

D Kalderon, W D Richardson, A F Markham, A E Smith

Sequence requirements for nuclear location of simian virus 40 large-T antigen

D Kalderon et al. Nature. 1984 Sep.

Abstract

A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that was detected in the cytoplasm but not the nucleus of cells. Deletions within the surrounding sequence Lys-128Lys-Lys-Arg-Lys-Val-Glu also produce cytoplasmic large-T and define a region of the protein involved in nuclear location.

PubMed Disclaimer

Substances

LinkOut - more resources