Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021:1301:1-5.
doi: 10.1007/978-3-030-62026-4_1.

Ferroptosis: Concepts and Definitions

Andrés F Flórez  1 , Hamed Alborzinia  2
Affiliations

Ferroptosis: Concepts and Definitions

Andrés F Flórez et al. Adv Exp Med Biol. 2021.

Abstract

Ferroptosis is a newly discovered form of cell death that is rapidly becoming associated to a variety of diseases and explaining their pathological mechanisms. This book addresses new emerging topics in the field of ferroptosis, with special attention to diseases more recently explained through ferroptotic mechanisms, including infectious diseases and neurodegeneration. In this chapter, we will provide the readers with an introduction to the concepts and pathways involved in ferroptosis to further move into a more detailed exposition of the topics advertised in this book. In special, we aim for this book to broaden the perspectives on how ferroptosis is regulated and connected to human diseases and motivate new studies in this emerging field.

Keywords: Apoptosis; Ferroptosis; Hallmarks of ferroptosis; Pyroptosis; TfR1; Transsulfuration.

PubMed Disclaimer

References

    1. Agmon E, Solon J, Bassereau P, Stockwell BR (2018) Modeling the effects of lipid peroxidation during ferroptosis on membrane properties. Sci Rep 8(1):5155. https://doi.org/10.1038/s41598-018-23408-0 - DOI - PubMed - PMC
    1. Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL (2009) Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 390(3):191–214. https://doi.org/10.1515/BC.2009.033 - DOI - PubMed - PMC
    1. Bergsbaken T, Fink SL, Cookson BT (2009) Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 7(2):99–109. https://doi.org/10.1038/nrmicro2070 - DOI - PubMed - PMC
    1. Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575(7784):688–692. https://doi.org/10.1038/s41586-019-1705-2 - DOI - PubMed - PMC
    1. Choi ME, Price DR, Ryter SW, Choi AMK (2019) Necroptosis: a crucial pathogenic mediator of human disease. JCI Insight 4(15). https://doi.org/10.1172/jci.insight.128834

LinkOut - more resources