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Review
. 2020 Nov;30(11):881-891.
doi: 10.1016/j.tcb.2020.09.002. Epub 2020 Oct 6.

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Matías González-Quiroz  1 , Alice Blondel  2 , Alfredo Sagredo  3 , Claudio Hetz  4 , Eric Chevet  2 , Rémy Pedeux  5
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Free article
Review

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Matías González-Quiroz et al. Trends Cell Biol. 2020 Nov.
Free article

Abstract

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer. We discuss the emerging signaling crosstalk between UPR stress sensors and the DDR, as well as their involvement in cancer biology.

Keywords: ATM; DNA damage response; IRE1α; PERK; proteostasis; unfolded protein response.

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