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Comment
. 2020 Jan 7;31(1):15-17.
doi: 10.1016/j.cmet.2019.12.008.

The Integrated Stress Response: A Central Memory Switch in Down Syndrome

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The Integrated Stress Response: A Central Memory Switch in Down Syndrome

Susanna Rosi et al. Cell Metab. .
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Abstract

Genetic and pharmacological evidence causally demonstrate that the integrated stress response (ISR) is a central molecular switch for long-term memory formation across different species. Zhu et al. (2019) recently demonstrated that persistent activation of the ISR could explain the long-term memory and synaptic plasticity deficits in a mouse model of Down syndrome, the most common genetic cause of intellectual disability.

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