The Integrated Stress Response: A Central Memory Switch in Down Syndrome
- PMID: 31951566
- DOI: 10.1016/j.cmet.2019.12.008
The Integrated Stress Response: A Central Memory Switch in Down Syndrome
Abstract
Genetic and pharmacological evidence causally demonstrate that the integrated stress response (ISR) is a central molecular switch for long-term memory formation across different species. Zhu et al. (2019) recently demonstrated that persistent activation of the ISR could explain the long-term memory and synaptic plasticity deficits in a mouse model of Down syndrome, the most common genetic cause of intellectual disability.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome.Science. 2019 Nov 15;366(6467):843-849. doi: 10.1126/science.aaw5185. Science. 2019. PMID: 31727829 Free PMC article.
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