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Review
. 2019 Jan;21(1):102-112.
doi: 10.1038/s41556-018-0196-y. Epub 2019 Jan 2.

Non-redundant functions of EMT transcription factors

Marc P Stemmler  1 , Rebecca L Eccles  1 , Simone Brabletz  1 , Thomas Brabletz  2
Affiliations
Review

Non-redundant functions of EMT transcription factors

Marc P Stemmler et al. Nat Cell Biol. 2019 Jan.

Abstract

Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.

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