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Review
. 2017 Dec;1868(2):584-591.
doi: 10.1016/j.bbcan.2017.06.006. Epub 2017 Jun 29.

EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET

Steven Goossens  1 , Niels Vandamme  2 , Pieter Van Vlierberghe  3 , Geert Berx  4
Affiliations
Review

EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET

Steven Goossens et al. Biochim Biophys Acta Rev Cancer. 2017 Dec.

Abstract

Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.

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