Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun;18(6):38.
doi: 10.1007/s11936-016-0461-y.

Hippo/Yap Signaling in Cardiac Development and Regeneration

Yang Xiao  1   2 , John Leach  1 , Jun Wang  1 , James F Martin  3   4   5   6   7
Affiliations
Review

Hippo/Yap Signaling in Cardiac Development and Regeneration

Yang Xiao et al. Curr Treat Options Cardiovasc Med. 2016 Jun.

Abstract

The heart has historically been considered to be a non-regenerative organ. Recent insights have suggested that cardiomyocytes have a small but measurable ability to regenerate. Moreover, recent work has also shown that manipulating the expression of specific genetic pathways can improve the ability of the heart to repair itself. These new insights set the stage for the development of new treatments for heart failure.

Keywords: Cardiac development; Cardiac regeneration; Hippo/Yap signaling.

PubMed Disclaimer

References

    1. Cancer Cell. 2009 Nov 6;16(5):425-38 - PubMed
    1. Sci Signal. 2011 Oct 25;4(196 ):ra70 - PubMed
    1. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1446-51 - PubMed
    1. Circ Res. 2014 Jul 18;115(3):354-63 - PubMed
    1. Cell. 2006 Jan 27;124(2):267-73 - PubMed

LinkOut - more resources