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Review
. 2016 Jun 10;584(1):17-25.
doi: 10.1016/j.gene.2016.03.002. Epub 2016 Mar 3.

Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation

Hyun Min Kim  1 , Jeong Woo Han  1 , Jefferson Y Chan  2
Affiliations
Review

Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation

Hyun Min Kim et al. Gene. .

Abstract

Nrf1 (also referred to as NFE2L1) is a member of the CNC-bZIP family of transcription factors that are characterized by a highly conserved CNC-domain, and a basic-leucine zipper domain required for dimerization and DNA binding. Nrf1 is ubiquitously expressed across tissue and cell types as various isoforms, and is induced by stress signals from a broad spectrum of stimuli. Evidence indicates that Nrf1 plays an important role in regulating a range of cellular functions including oxidative stress response, differentiation, inflammatory response, metabolism, and maintaining proteostasis. Thus, Nrf1 has been implicated in the pathogenesis of various disease processes including cancer development, and degenerative and metabolic disorders. This review summarizes our current understanding of Nrf1 and the molecular mechanism underlying its regulation and action in different cellular functions.

Keywords: Antioxidant; Antioxidant response element; CNC-bZIP; Cellular stress response; Proteostasis; Transcription factor; proteasome regulation.

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Figures

Figure 1.
Figure 1.
Nrf1 function is subject to transcriptional and post-translational regulation. This diagram depicts the pathways that have been identified that control the expression, activity and stability of NRF1. See text for explanation.
See this image and copyright information in PMC

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