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. 2014 Oct 13;26(4):534-48.
doi: 10.1016/j.ccell.2014.09.002.

Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages

Dennis Shin-Shian Hsu  1 , Hsiao-Jung Wang  1 , Shyh-Kuan Tai  2 , Chun-Hung Chou  1 , Chia-Hsin Hsieh  3 , Po-Hsien Chiu  1 , Nien-Jung Chen  4 , Muh-Hwa Yang  5
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Free article

Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages

Dennis Shin-Shian Hsu et al. Cancer Cell. .
Free article

Abstract

Snail is primarily known as a transcriptional repressor that induces epithelial-mesenchymal transition by suppressing adherent proteins. Emerging evidence suggests that Snail can act as an activator; however, the mechanism and biological significance are unclear. Here, we found that CREB-binding protein (CBP) is the critical factor in Snail-mediated target gene transactivation. CBP interacts with Snail and acetylates Snail at lysine 146 and lysine 187, which prevents the repressor complex formation. We further identified several Snail-activated targets, including TNF-α, which is also the upstream signal for Snail acetylation, and CCL2 and CCL5, which promote the recruitment of tumor-associated macrophages. Here, we present our results on the mechanism by which Snail induces target gene transactivation to remodel the tumor microenvironment.

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