Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Sep 2;20(3):385-7.
doi: 10.1016/j.cmet.2014.07.009.

Cell-nonautonomous control of the UPR: mastering energy homeostasis

Pablo Mardones  1 , Andrew Dillin  2 , Claudio Hetz  3
Affiliations
Free article
Comment

Cell-nonautonomous control of the UPR: mastering energy homeostasis

Pablo Mardones et al. Cell Metab. .
Free article

Abstract

Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) in hypothalamic neurons are common features of obesity, resulting in leptin and insulin resistance. In this issue, Williams et al. (2014) demonstrate, for the first time, cell-nonautonomous UPR signaling between brain and liver in the context of glucoregulation.

PubMed Disclaimer

Comment on

Publication types

LinkOut - more resources