Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 May 12;25(5):563-73.
doi: 10.1016/j.ccr.2014.03.015.

Endoplasmic reticulum stress in malignancy

Hanna J Clarke  1 , Joseph E Chambers  1 , Elizabeth Liniker  1 , Stefan J Marciniak  2
Affiliations
Free article
Review

Endoplasmic reticulum stress in malignancy

Hanna J Clarke et al. Cancer Cell. .
Free article

Abstract

The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources