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. 2014 Jun 21;50(49):6454-7.
doi: 10.1039/c4cc01210k. Epub 2014 May 9.

TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

Wen-Jing Yi  1 , Xing-Chi Yu, Bing Wang, Ji Zhang, Qing-Ying Yu, Xue-Dong Zhou, Xiao-Qi Yu
Affiliations

TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

Wen-Jing Yi et al. Chem Commun (Camb). .

Abstract

Cationic oligomers with a rigid aromatic backbone were first applied as non-viral gene delivery vectors. These materials showed better DNA condensation ability than their flexible analogues. In vitro transfection experiments revealed that the materials with more rigid backbone exhibited considerably higher TE and lower cytotoxicity than 25 kDa PEI.

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