Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan;34(1):167-9.
doi: 10.1128/AAC.34.1.167.

Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do

K Riesbeck  1 , A Bredberg, A Forsgren
Affiliations

Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do

K Riesbeck et al. Antimicrob Agents Chemother. 1990 Jan.

Abstract

At clinical concentrations, ciprofloxacin did not inhibit mitochondrial DNA replication, oxidative phosphorylation, protein synthesis, or mitochondrial mass (transmembrane potential). No difference in supercoiled forms of DNA was observed. The tetracyclines and chloramphenicol inhibited protein synthesis at clinically achievable concentrations, while rifampin, fusidic acid, and clindamycin did not.

PubMed Disclaimer

References

    1. Infect Immun. 1985 May;48(2):556-9 - PubMed
    1. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8 - PubMed
    1. J Antimicrob Chemother. 1988 May;21(5):597-607 - PubMed
    1. J Biol Chem. 1989 Feb 15;264(5):2973-8 - PubMed
    1. Pharm Weekbl Sci. 1983 Jun 24;5(3):81-7 - PubMed