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Review
. 2012 Sep;160(1):83-92.
doi: 10.1104/pp.112.200956. Epub 2012 Jul 27.

Gibberellin signaling: a theme and variations on DELLA repression

Amber L Hauvermale  1 , Tohru Ariizumi, Camille M Steber
Affiliations
Review

Gibberellin signaling: a theme and variations on DELLA repression

Amber L Hauvermale et al. Plant Physiol. 2012 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Proteolysis-dependent and -independent GA signaling models. A, The canonical GA signaling model illustrating GA-dependent GID1-DELLA complex formation resulting in DELLA recognition and ubiquitylation by the SCFSLY1 E3. Polyubiquitylation leads to DELLA proteolysis by the 26S proteasome, thereby lifting DELLA repression of GA responses. B, Proteolysis-independent GA signaling in sly1 mutants occurs when GID1-GA-DELLA complex formation blocks DELLA repression of GA responses without DELLA destruction. C, EL1-mediated phosphorylation of DELLA activates DELLA as a repressor of GA responses.
Figure 2.
Figure 2.
DELLA protein organization illustrating the conserved domains and subdomains involved in GID1 binding (purple), target binding (blue), nuclear localization (gray), and SLY1/GID2 binding (green). Also depicted are the invariant Arg (R) and Tyr residues (Y) conserved among the STAT-like GRAS protein family and specific Ser residues (Ser-196 and Ser-510) that are sites of EL1-directed phosphorylation.
Figure 3.
Figure 3.
A, Downstream DELLA targets negatively regulated through confirmed protein-protein interactions with DELLA. B, Suggested model for DELLA modulation of PIF activity in response to light and the clock. In the night, GA and GID1 levels are highest, thus repressing DELLA’s ability to negatively regulate PIF. PIF mRNA levels rise during the night, leading to rapid hypocotyl growth before morning. At dawn, a drop in GID1 levels results in DELLA stabilization and repression of PIF, leading to greening and slower growth. In the day, red light actives Pfr, which phosphorylates PIF, leading to PIF destruction via the ubiquitin-proteasome pathway. Lack of PIF blocks hypocotyl growth.
See this image and copyright information in PMC

References

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