Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr 15;485(7396):114-8.
doi: 10.1038/nature10962.

A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases

Feng Feng  1 , Fan Yang, Wei Rong, Xiaogang Wu, Jie Zhang, She Chen, Chaozu He, Jian-Min Zhou
Affiliations

A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases

Feng Feng et al. Nature. .

Abstract

Plant innate immunity is activated on the detection of pathogen-associated molecular patterns (PAMPs) at the cell surface, or of pathogen effector proteins inside the plant cell. Together, PAMP-triggered immunity and effector-triggered immunity constitute powerful defences against various phytopathogens. Pathogenic bacteria inject a variety of effector proteins into the host cell to assist infection or propagation. A number of effector proteins have been shown to inhibit plant immunity, but the biochemical basis remains unknown for the vast majority of these effectors. Here we show that the Xanthomonas campestris pathovar campestris type III effector AvrAC enhances virulence and inhibits plant immunity by specifically targeting Arabidopsis BIK1 and RIPK, two receptor-like cytoplasmic kinases known to mediate immune signalling. AvrAC is a uridylyl transferase that adds uridine 5'-monophosphate to and conceals conserved phosphorylation sites in the activation loop of BIK1 and RIPK, reducing their kinase activity and consequently inhibiting downstream signalling.

PubMed Disclaimer

References

    1. Science. 2006 May 26;312(5777):1211-4 - PubMed
    1. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):496-501 - PubMed
    1. Plant Cell. 2011 Aug;23(8):2831-49 - PubMed
    1. Mol Plant Pathol. 2007 Jul;8(4):437-50 - PubMed
    1. Nature. 2011 Aug 07;477(7362):103-6 - PubMed

Publication types

MeSH terms

Substances