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. 2011 Dec 9;334(6061):1405-8.
doi: 10.1126/science.1211592.

Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators

Saikat Bhattacharjee  1 , Morgan K Halane, Sang Hee Kim, Walter Gassmann
Affiliations

Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators

Saikat Bhattacharjee et al. Science. .

Erratum in

  • Science. 2012 Jan 13;335(6065):167

Abstract

Plant resistance proteins detect the presence of specific pathogen effectors and initiate effector-triggered immunity. Few immune regulators downstream of resistance proteins have been identified, none of which are known virulence targets of effectors. We show that Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), a positive regulator of basal resistance and of effector-triggered immunity specifically mediated by Toll-interleukin-1 receptor-nucleotide binding-leucine-rich repeat (TIR-NB-LRR) resistance proteins, forms protein complexes with the TIR-NB-LRR disease resistance proteins RPS4 and RPS6 and with the negative immune regulator SRFR1 at a cytoplasmic membrane. Further, the cognate bacterial effectors AvrRps4 and HopA1 disrupt these EDS1 complexes. Tight association of EDS1 with TIR-NB-LRR-mediated immunity may therefore derive mainly from being guarded by TIR-NB-LRR proteins, and activation of this branch of effector-triggered immunity may directly connect to the basal resistance signaling pathway via EDS1.

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