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. 2011 Nov 13;18(12):1432-4.
doi: 10.1038/nsmb.2173.

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

Ivan V Rosado  1 , Frédéric Langevin, Gerry P Crossan, Minoru Takata, Ketan J Patel
Affiliations

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

Ivan V Rosado et al. Nat Struct Mol Biol. .

Abstract

Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.

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  • ICLs: a chicken without an egg.
    Bekker-Jensen S, Mailand N. Bekker-Jensen S, et al. Nat Rev Mol Cell Biol. 2012 Apr 25;13(6):342. doi: 10.1038/nrm3348. Nat Rev Mol Cell Biol. 2012. PMID: 22531379 No abstract available.

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