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. 2012 Feb;98(2-3):264-8.
doi: 10.1016/j.eplepsyres.2011.09.016. Epub 2011 Oct 12.

Aquaporin-4-dependent edema clearance following status epilepticus

Darrin J Lee  1 , Mariam Amini, Mark J Hamamura, Mike S Hsu, Marcus M Seldin, Orhan Nalcioglu, Devin K Binder
Affiliations

Aquaporin-4-dependent edema clearance following status epilepticus

Darrin J Lee et al. Epilepsy Res. 2012 Feb.

Abstract

We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6 h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and T2 MRI changes in AQP4(-/-) compared to AQP4(+/+) mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity.

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