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. 1990 May;188(1):55-60.
doi: 10.1016/0014-4827(90)90277-h.

Antibody to integrin alpha 6 subunit specifically inhibits cell-binding to laminin fragment 8

M Aumailley  1 , R Timpl, A Sonnenberg
Affiliations

Antibody to integrin alpha 6 subunit specifically inhibits cell-binding to laminin fragment 8

M Aumailley et al. Exp Cell Res. 1990 May.

Abstract

A large number of cell lines which attach and spread on laminin show a comparable binding either to both laminin fragments P1 and E8 or exclusively to E8. Adhesion to fragment E8 was with one exception completely inhibited by a monoclonal antibody to the alpha 6 integrin subunit, indicating that VLA-6 or a related structure is the major cellular receptor for laminin. It is not involved in fragment P1 adhesion. Synthetic peptides possessing RGD or YIGSR sequences were without inhibitory activity for alpha 6-mediated adhesion to fragment E8.

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