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Review
. 2011 Mar;10(3):188-95.
doi: 10.1038/nrd3368.

Impact of high-throughput screening in biomedical research

Ricardo Macarron  1 , Martyn N Banks, Dejan Bojanic, David J Burns, Dragan A Cirovic, Tina Garyantes, Darren V S Green, Robert P Hertzberg, William P Janzen, Jeff W Paslay, Ulrich Schopfer, G Sitta Sittampalam
Affiliations
Review

Impact of high-throughput screening in biomedical research

Ricardo Macarron et al. Nat Rev Drug Discov. 2011 Mar.

Abstract

High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.

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References

    1. J Med Chem. 2002 Aug 15;45(17):3573-5 - PubMed
    1. Comb Chem High Throughput Screen. 2008 Aug;11(7):523-36 - PubMed
    1. Curr Drug Discov Technol. 2008 Mar;5(1):59-69 - PubMed
    1. J Biomol Screen. 2005 Sep;10(6):615-23 - PubMed
    1. Drug Discov Today. 2007 Oct;12(19-20):820-5 - PubMed

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