Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar;10(3):210-5.
doi: 10.1038/nri2725. Epub 2010 Feb 19.

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

Jurg Tschopp  1 , Kate Schroder
Affiliations
Review

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

Jurg Tschopp et al. Nat Rev Immunol. 2010 Mar.

Abstract

The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).

PubMed Disclaimer

References

    1. Immunity. 2009 Apr 17;30(4):556-65 - PubMed
    1. Nat Immunol. 2008 Aug;9(8):857-65 - PubMed
    1. J Immunol. 2008 Mar 15;180(6):4050-7 - PubMed
    1. J Biol Chem. 1994 May 27;269(21):15195-203 - PubMed
    1. Immunity. 2004 Mar;20(3):319-25 - PubMed

Publication types

MeSH terms

LinkOut - more resources