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Review
. 2009 Oct;10(10):982-1000.
doi: 10.2174/138945009789578007.

Efficacy and safety of the combination of docetaxel (Taxotere) with targeted therapies in the treatment of solid malignancies

Vincenzo Emanuele Chiuri  1 , Nicola Silvestris, Vito Lorusso, Andrea Tinelli
Affiliations
Review

Efficacy and safety of the combination of docetaxel (Taxotere) with targeted therapies in the treatment of solid malignancies

Vincenzo Emanuele Chiuri et al. Curr Drug Targets. 2009 Oct.

Abstract

Docetaxel is a chemotherapeutic drug which has recently demonstrated high efficacy in the treatment of a wide variety of tumors. Numerous novel targeted drugs are being introduced in preclinical and clinical practice, aiming to directly inhibit pathways responsible for the maintenance of transformed and immortalized phenotypes of cancer cells. Herein we reported the efficacy and safety results of the most significant clinical trials evaluating different combinations and schedules of docetaxel plus biological therapeutics.

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