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. 2009 Jul;30(5):617-25.
doi: 10.1007/s00246-009-9391-8. Epub 2009 Mar 10.

Epicardial control of myocardial proliferation and morphogenesis

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Epicardial control of myocardial proliferation and morphogenesis

Henry M Sucov et al. Pediatr Cardiol. 2009 Jul.

Abstract

The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.

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