Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Apr 24;284(17):11001-5.
doi: 10.1074/jbc.R800073200. Epub 2008 Dec 17.

Rassf family of tumor suppressor polypeptides

Joseph Avruch  1 , Ramnik Xavier, Nabeel Bardeesy, Xian-Feng Zhang, Maria Praskova, Dawang Zhou, Fan Xia
Affiliations
Review

Rassf family of tumor suppressor polypeptides

Joseph Avruch et al. J Biol Chem. .

Abstract

The Rassf1-6 polypeptides each contain a Ras/Rap association domain, which enables binding to several GTP-charged Ras-like GTPases, at least in vitro or when overexpressed. The Ras/Rap association domains are followed by SARAH domains, which mediate Rassf heterodimerization with the Mst1/2 protein kinases. Rassf1A is unequivocally a tumor suppressor, and all Rassf proteins behave like tumor suppressors, exhibiting epigenetic silencing of expression in many human cancers and pro-apoptotic and/or anti-proliferative effects when re-expressed in tumor cell lines. Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function.

PubMed Disclaimer

Figures

FIGURE 1.
FIGURE 1.
Signal transduction through the Nore1/Rassf5 and Rassf1A polypeptides. Question marks indicate that the identity of the element(s) or the relationship indicated by the arrows is uncertain. The dashed line indicates definite but weak signaling. GEFs, guanine nucleotide exchange factors.
See this image and copyright information in PMC

Comment in

  • Thinking outside the box about Ras.
    Kyriakis JM. Kyriakis JM. J Biol Chem. 2009 Apr 24;284(17):10993-4. doi: 10.1074/jbc.R800085200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091742 Free PMC article. Review. No abstract available.

References

    1. Vavvas, D., Avruch, J., and Zhang, X.-f. (1998) J. Biol. Chem. 273, 5439–5442 - PubMed
    1. Dammann, R., Li, C., Yoon, J.-H., Chin, P. L., Bates, S., and Pfeifer, D. P. (2000) Nat. Genet. 25, 315–319 - PubMed
    1. Zabarovsky, E. R., Lerman, M. I., and Minna, J. D. (2002) Oncogene 21, 6915–6935 - PubMed
    1. Hesson, L. B., Cooper, W. N., and Latif, F. (2007) Oncogene 26, 7283–7301 - PubMed
    1. Donninger, H., Vos, M. D., and Clark, G. J. (2007) J. Cell Sci. 120, 3163–3172 - PubMed

Publication types