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. 1991 Jul 15;103(1):133-4.
doi: 10.1016/0378-1119(91)90405-z.

Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases

M Arthur  1 , C Molinas, S Dutka-Malen, P Courvalin
Affiliations

Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases

M Arthur et al. Gene. .

Abstract

Sequencing upstream from the vanA gene of enterococcal plasmid pIP816 that confers Vm resistance revealed the presence of an ORF which could code for a protein of 322 aa designated VanH. Extensive aa similarity was detected between VanH and 2-hydroxycarboxylic acid dehydrogenase. We discuss possible roles for VanH in the synthesis of a novel type of peptidoglycan precursors with lower affinity for Vm.

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