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Review
. 1991 Jan 10;349(6305):117-27.
doi: 10.1038/349117a0.

The GTPase superfamily: conserved structure and molecular mechanism

H R Bourne  1 , D A Sanders, F McCormick
Affiliations
Review

The GTPase superfamily: conserved structure and molecular mechanism

H R Bourne et al. Nature. .

Abstract

GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases--crystal structures, biochemical properties, or results of molecular genetic experiments--support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.

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