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Review
. 2008 Jun;28(6):735-9.
doi: 10.1016/j.immuni.2008.05.005.

Regulation of mitochondrial antiviral signaling pathways

Chris B Moore  1 , Jenny P-Y Ting
Affiliations
Free article
Review

Regulation of mitochondrial antiviral signaling pathways

Chris B Moore et al. Immunity. 2008 Jun.
Free article

Abstract

Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.

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