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Comparative Study
. 2007 Jun;29(4):348-55.
doi: 10.1179/016164107X204657.

Extent of nerve cell injury in Marmarou's model compared to other brain trauma models

José A Rafols  1 , Randy Morgan, Srinivas Kallakuri, Christian W Kreipke
Affiliations
Comparative Study

Extent of nerve cell injury in Marmarou's model compared to other brain trauma models

José A Rafols et al. Neurol Res. 2007 Jun.

Retraction in

  • Statement of retraction.
    [No authors listed] [No authors listed] Neurol Res. 2017 May;39(5):472. doi: 10.1080/01616412.2017.1288458. Epub 2017 Feb 23. Neurol Res. 2017. PMID: 28229623 No abstract available.

Abstract

Objectives: We sought to determine the extent of nerve cell injury in the Marmarou's acceleration impact model of diffuse brain injury.

Methods: Sensitive markers for cell injury including immunostaining for beta-amyloid precursor protein (beta-APP, a marker for diffuse axonal injury, DAI), Fluoro-Jade (FJ) histochemistry and electron microscopy (EM) were used in sham-operated and traumatized brains.

Results: APP immunostaining confirmed and extended previous findings of DAI in association and subcortical fiber systems in the white matter after injury. Increasing FJ labeling of neurons in layers II-III of sensorimotor cortex (smCx) from 4 to 48 hours after trauma and scattered labeled cells were found in the lower cortical layers. EM confirmed the presence of dystrophic pyramidal neurons in layers II-III of smCx 24 and 48 hours post-trauma.

Discussion: Taken together, the data revealed significant nerve cell injury without apparent cell death in this model.

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